期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 23, 期 7, 页码 765-778出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520622666220831124321
关键词
Sanguinarine; cancer; natural agent; nanoparticle; molecular target; chemo-preventive effects
In this critical study, the utilization of Sanguinarine (SANG) mimics and nano-technologies to improve its support in cancer treatment is reviewed, with a focus on recently disclosed studies on the anti-cancer properties of SANG.
Historically, natural plant-derived drugs received a great impact of consideration in the treatment of several human-associated disorders. Cancer is a devastating disease and the second most cause of mortality. Sanguinarine (SANG), a naturally isolated plant alkaloidal agent, possesses chemo-preventive effects. Several studies have revealed that SANG impedes tumor metastasis and development by disrupting a wide range of cell signaling pathways and its molecular targets, such as BCL-2, MAPKs, Akt, NF-kappa B, ROS, and microRNAs (miRNAs). However, its low chemical stability and poor oral bioavailability remain key issues in its use as a medicinal molecule. A novel method (e.g., liposomes, nanoparticles, and micelles) and alternative analogs provide an exciting approach to alleviate these problems and broaden its pharmacokinetic profile. Cancer-specific miRNA expression is synchronized by SANG, which has also been uncertain. In this critical study, we review the utilization of SANG mimics and nano-technologies to improve its support in cancer. We focus on recently disclosed studies on SANG anti-cancer properties.
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