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Metabolic Recruitment in Brain Tissue

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Summary: Previously, it was believed that the energy cost of information processing was mainly attributed to neurons, with a minor fraction allocated to glial cells. However, there is compelling evidence that astrocytes also contribute significantly to this energy cost as they actively capture synaptic K+ using their Na+/K+ ATPase. This finding challenges the previous belief that astrocytes solely rely on Kir4.1 channels for K+ uptake. The implications of this discovery for reactive astrogliosis and brain diseases are discussed.

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