4.5 Review

Endoplasmic ReticulumPlasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Physiology

Physiological Functions of CRAC Channels

Scott M. Emrich et al.

Summary: Store-operated Ca2+ entry (SOCE) is a common and evolutionarily conserved Ca2+ signaling pathway in eukaryotes. Recent studies have investigated the composition and physiological functions of CRAC channels in various tissues, providing insights into the importance of SOCE in different cellular systems.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

Review Physiology

THE ROLE OF JUNCTOPHILIN PROTEINS IN CELLULAR FUNCTION

Stephan E. Lehnart et al.

Summary: Junctophilins (JPH5) are structural proteins that connect the plasma membrane to intracellular organelles, playing important roles in signaling. Deficiencies and mutations in JPH isoforms can lead to various diseases.

PHYSIOLOGICAL REVIEWS (2022)

Article Biology

STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

Vivek Krishnan et al.

Summary: Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) is important for regulating the function of vascular smooth muscle cells (VSMCs). The protein STIM1 plays a critical role in maintaining this coupling in contractile VSMCs, independent of the depletion of SR Ca2+ stores.
Review Physiology

Nanoscale Organization, Regulation, and Dynamic Reorganization of Cardiac Calcium Channels

Rose E. Dixon

Summary: The organization and distribution of calcium channel clusters in cardiomyocytes are crucial for uniform contraction of myocardium. Signaling between these clusters generates Ca2+ sparks, which summate to produce global Ca2+ transients that activate the myofilaments for myocardial contraction. The heart responds to metabolic demands through altering calcium channel activity, and recent evidence suggests a role for dynamic reorganization of these channels in controlling myocardial function.

FRONTIERS IN PHYSIOLOGY (2022)

Review Biochemistry & Molecular Biology

Phosphoinositide transport and metabolism at membrane contact sites

Eamonn J. Dickson

Summary: Phosphoinositides, a family of signaling lipids, play a crucial role in regulating protein function at the interface between cellular membranes. Mutations or changes in phosphoinositide metabolizing enzymes can lead to various disorders, such as developmental, neurodegenerative, and metabolic disorders, which have devastating effects on human health. This review focuses on the transport and metabolism of phosphoinositide lipids at membrane contact sites.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2022)

Review Physiology

Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling

Laura Guarina et al.

Summary: Each heartbeat begins with an action potential in pacemaking cells, triggering cardiac muscle contraction through excitation-contraction coupling. Recent findings suggest that the high reproducibility of cardiac contraction is paradoxically due to high calcium signaling variability at subcellular, cellular, and network levels caused by stochastic fluctuations in ion channels and dyadic structure.

JOURNAL OF GENERAL PHYSIOLOGY (2022)

Article Multidisciplinary Sciences

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations

Zheng Fang Yang et al.

Summary: Junctophilins (JPH) are proteins that connect the plasma membrane and the endoplasmic or sarcoplasmic reticulum, facilitating communication between proteins in different membranes. This study presents crystal structures of two JPH isoforms, revealing their importance in muscle excitation-contraction coupling. Various mutations in JPH2 and the L-type calcium channel affect their interaction and have been linked to cardiomyopathy and cardiac arrhythmia, respectively.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Biochemistry & Molecular Biology

The MORN domain of Junctophilin2 regulates functional interactions with small-conductance Ca2+-activated potassium channel subtype2 (SK2)

Tianxia Luo et al.

Summary: The study confirms the physical interactions between JP2 and SK2 channels, highlighting the essential role of the JP2 MORN domain in membrane expression and retrograde trafficking of SK2 channels, as well as direct modulation of SK2 channel current amplitude.

BIOFACTORS (2021)

Article Cardiac & Cardiovascular Systems

Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

Claire Poulet et al.

Summary: JPH2 promotes T-tubule structural stability and recruits functional LTCCs to the membrane, most likely by directly binding to the channel. Cholesterol is involved in the binding of JPH2 to T-tubules as well as in the modulation of LTCC activity.

CARDIOVASCULAR RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics

Polina Gross et al.

Summary: The joining region in JPH2 interacts with LTCC-alpha 1C subunit, causing LTCCs to distribute to dyads and colocalize with RyRs, facilitating dyad assembly and maintaining normal CICR in cardiomyocytes. Disruption of this interaction leads to T-tubule remodeling, impaired excitation-contraction coupling, and altered myocyte bioenergetics.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange

Eva A. Rog-Zielinska et al.

Summary: The sarcolemma of cardiomyocytes contains important proteins essential for electromechanical function, with TT playing a crucial role in supporting electromechanical synchronicity within cells. This study suggests the presence of an advective component to TT content exchange, which assists in equilibration with bulk extracellular fluid. The mechanical state of cardiomyocytes affects the speed of diffusion within TT, with cyclic contractile activity accelerating TT diffusion dynamics.

CIRCULATION RESEARCH (2021)

Article Multidisciplinary Sciences

A multimodal cell census and atlas of the mammalian primary motor cortex

Edward M. Callaway et al.

Summary: This study presents a multimodal cell census and atlas of the mammalian primary motor cortex, integrating various molecular and spatial information to reveal a unified genetic landscape of cortical cell types. The results establish a mechanistic framework of neuronal cell-type organization by linking molecular genetic information with phenotypic properties.

NATURE (2021)

Article Neurosciences

Synaptophysin Regulates Fusion Pores and Exocytosis Mode in Chromaffin Cells

Che-Wei Chang et al.

Summary: This study demonstrates that Synaptophysin (Syp) and synaptogyrin (Syg) play a regulatory role in dense-core vesicle function at various stages, affecting fusion initiation, mode selection between full fusion and kiss-and-run, and influencing the dynamics of both initial and late-stage fusion pores. The transmembrane domain (TMD) of Syp influences small initial fusion pores, while the C-terminal domain influences large late-stage fusion pores, possibly through an interaction with dynamin.

JOURNAL OF NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM junctions

Nicholas C. Vierra et al.

Summary: In mammalian brain neurons, membrane depolarization triggers Ca2+ influx through voltage-gated Ca2+ channels, leading to diverse cellular responses, including gene expression. The L-type Ca2+ channels in neuronal soma and dendrites play a key role in this process. The organization of signaling complexes by Kv2.1 at endoplasmic reticulum-plasma membrane junctions enhances the clustering and activity of Cav1.2 channels, impacting somatic Ca2+ signals and excitation-transcription coupling.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

β-Adrenergic control of sarcolemmal CaV1.2 abundance by small GTPase Rab proteins

Silvia G. del Villar et al.

Summary: The number and activity of Ca(v)1.2 channels in cardiomyocytes regulates the magnitude of Ca2+-induced Ca2+ release and myocardial contraction. Stimulation of beta-Adrenergic receptors leads to insertion of Ca(V)1.2 channels into the sarcolemma, enhancing cooperative gating behavior and increasing Ca2+ influx and contractility. This process is fueled by an internal reserve of pre-synthesized channels localized in endosomes, regulated by Rab proteins.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Endoplasmic Reticulum-Plasma Membrane Contact Sites: Regulators, Mechanisms, and Physiological Functions

Chenlu Li et al.

Summary: Endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma membrane (PM) in eukaryotic cells, playing crucial roles in lipid homeostasis, ion dynamics, and cell signaling through protein-protein or protein-lipid interactions. Distinct tethering factors dynamically regulate the architecture of ER-PM junctions in response to signals, and the physiological roles of these contact sites rely on various regulators acting in diverse cellular processes. This review focuses on proteins at ER-PM contact sites, highlighting recent progress in their mechanisms and physiological roles.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Physiology

Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart

Yufeng Hou et al.

Summary: Disruption in the organization of the ryanodine receptors (RyR) and junctophilin (JPH) may contribute to the transverse tubule remodelling in a failing heart. Advanced imaging techniques showed a correlation between the t-sheets and collagen deposits, while also revealing changes in the expression and distribution of RyR and JPH in the failing heart. This study suggests that reduced RyR expression and altered t-tubule organization may play a role in the decreased excitation-contraction coupling in failing human hearts.

FRONTIERS IN PHYSIOLOGY (2021)

Article Neurosciences

Functional Microstructure of CaV-Mediated Calcium Signaling in the Axon Initial Segment

Anna M. Lipkin et al.

Summary: The study revealed that in mouse layer 5 prefrontal pyramidal neurons, calcium channels were distributed differently, with Ca(V)3 channels leading to high-spot calcium influx in specific regions, while Ca(V)2 channels localized to non-hotspot areas.

JOURNAL OF NEUROSCIENCE (2021)

Article Biology

Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

Stefano Perni et al.

Summary: Neuronal junctophilins JPH3 and JPH4 play important roles in the junctions between the endoplasmic reticulum and plasma membrane, interacting differently with various calcium channels and modifying the inactivation rate of Ca(V)2.1 and Ca(V)2.2.
Review Cell Biology

Regulation and physiology of membrane contact sites

Rossella Venditti et al.

Summary: This review focuses on the regulation and physiological roles of membrane contact sites (MCSs) in cells, tissues, and whole organisms. It discusses the dynamic response of MCSs to physiological stimuli, their molecular composition, and how mutations of MCS components related to genetic diseases can provide insights into their physiological relevance.

CURRENT OPINION IN CELL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation-contraction coupling

Britany Rufenach et al.

Summary: This review focuses on the mechanical coupling between Ca(V)1.1 and RyR1 in skeletal muscle tissue, the role of STAC3 as a critical player in this coupling, and the relevance of these connections for functional modulation and involvement in myopathy.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Cell Biology

Store-Operated Calcium Channels: From Function to Structure and Back Again

Richard S. Lewis

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2020)

Review Cell Biology

The functional universe of membrane contact sites

William A. Prinz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Cell Biology

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes

Benjamin M. Drum et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle

Samantha C. O'Dwyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

Endoplasmic reticulum-plasma membrane contacts: Principals of phosphoinositide and calcium signaling

Christopher J. Stefan

CURRENT OPINION IN CELL BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes

Simone Spinozzi et al.

CIRCULATION-HEART FAILURE (2020)

Article Medicine, Research & Experimental

Homozygous G650del nexilin variant causes in mice

Canzhao Liu et al.

JCI INSIGHT (2020)

Article Cardiac & Cardiovascular Systems

Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation

Canzhao Liu et al.

CIRCULATION (2019)

Article Biochemistry & Molecular Biology

S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane

Min Jiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers

Daniela Rossi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility

Harry A. T. Pritchard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Physiology

Junctional trafficking and restoration of retrograde signaling by the cytoplasmic RyR1 domain

Alexander Polster et al.

JOURNAL OF GENERAL PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular I-Ca density in mouse ventricular myocytes

Simon M. Bryant et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Multidisciplinary Sciences

Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction

Tsutomu Nakada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB

Ben Johnson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Physiology

Dyadic Plasticity in Cardiomyocytes

Peter P. Jones et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

A guide to the 3D structure of the ryanodine receptor type 1 by cryoEM

Montserrat Samso

PROTEIN SCIENCE (2017)

Review Neurosciences

Optogenetic Tools for Subcellular Applications in Neuroscience

Benjamin R. Rost et al.

NEURON (2017)

Article Multidisciplinary Sciences

Contacts between the endoplasmic reticulum and other membranes in neurons

Yumei Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release

Stefano Perni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

Nagendra Babu Thillaiappan et al.

NATURE COMMUNICATIONS (2017)

Article Cardiac & Cardiovascular Systems

Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis

Zouhair Aherrahrou et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

Article Biochemistry & Molecular Biology

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

Sarah E. Murphy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

Article Cardiac & Cardiovascular Systems

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release

Julia O. Reynolds et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Article Biochemistry & Molecular Biology

Calcium signaling at ER membrane contact sites

Thomas Burgoyne et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Cell Biology

Molecular mechanisms of inter-organelle ER-PM contact sites

W. Mike Henne et al.

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

Ang Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels

Philip D. Fox et al.

JOURNAL OF CELL SCIENCE (2015)

Review Physiology

STORE-OPERATED CALCIUM CHANNELS

Murali Prakriya et al.

PHYSIOLOGICAL REVIEWS (2015)

Review Cardiac & Cardiovascular Systems

Molecular and functional significance of Ca2+-activated Cl- channels in pulmonary arterial smooth muscle

Normand Leblanc et al.

PULMONARY CIRCULATION (2015)

Article Multidisciplinary Sciences

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

Zhen Yan et al.

NATURE (2015)

Article Cardiac & Cardiovascular Systems

Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1)

Jessica L. Caldwell et al.

CIRCULATION RESEARCH (2014)

Article Neurosciences

A Unique Ion Channel Clustering Domain on the Axon Initial Segment of Mammalian Neurons

Anna N. King et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2014)

Article Biochemistry & Molecular Biology

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia

TingTing Hong et al.

NATURE MEDICINE (2014)

Article Physiology

The Sarcoplasmic Reticulum and the Evolution of the Vertebrate Heart

Holly A. Shiels et al.

PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Cytosolic [Ca2+] regulation of InsP3-evoked puffs

Michiko Yamasaki-Mann et al.

BIOCHEMICAL JOURNAL (2013)

Review Biochemistry & Molecular Biology

Cav1.1: The atypical prototypical voltage-gated Ca2+ channel

Roger A. Bannister et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

Article Cardiac & Cardiovascular Systems

Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure

Hai-Bo Zhang et al.

CARDIOVASCULAR RESEARCH (2013)

Article Cardiac & Cardiovascular Systems

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development

Julia O. Reynolds et al.

CARDIOVASCULAR RESEARCH (2013)

Article Neurosciences

Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex

Dongxu Guan et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Article Cell Biology

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

Amber R. English et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Clinical Neurology

Loss of junctophilin-3 contributes to huntington disease-like 2 pathogenesis

Ana I. Seixas et al.

ANNALS OF NEUROLOGY (2012)

Review Physiology

Small-Conductance Ca2+-Activated K+ Channels: Form and Function

John P. Adelman et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)

Article Cardiac & Cardiovascular Systems

BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes

Ting-Ting Hong et al.

HEART RHYTHM (2012)

Article Multidisciplinary Sciences

Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels

Rose E. Dixon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Junctophilin 1 and 2 Proteins Interact with the L-type Ca2+ Channel Dihydropyridine Receptors (DHPRs) in Skeletal Muscle

Lucia Golini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

Amanda L. Vega et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

Article Genetics & Heredity

Mutations in NEXN, a Z-Disc Gene, Are Associated with Hypertrophic Cardiomyopathy

Hu Wang et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2010)

Article Cell Biology

Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells

Albert L. Gonzales et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Article Biophysics

Analysis of Cav1.2 and Ryanodine Receptor Clusters in Rat Ventricular Myocytes

David R. L. Scriven et al.

BIOPHYSICAL JOURNAL (2010)

Article Cardiac & Cardiovascular Systems

T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure

Sheng Wei et al.

CIRCULATION RESEARCH (2010)

Article Cardiac & Cardiovascular Systems

Excitation-contraction coupling changes during postnatal cardiac development

Andrew P. Ziman et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

Article Biochemistry & Molecular Biology

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

David Hassel et al.

NATURE MEDICINE (2009)

Article Cell Biology

Molecular evolution of the junctophilin gene family

Alejandro Garbino et al.

PHYSIOLOGICAL GENOMICS (2009)

Review Neurosciences

Control of KCa channels by calcium nano/microdomains

Bernd Fakler et al.

NEURON (2008)

Review Physiology

Calcium sparks

Heping Cheng et al.

PHYSIOLOGICAL REVIEWS (2008)

Article Genetics & Heredity

Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy

Yoshihisa Matsushita et al.

JOURNAL OF HUMAN GENETICS (2007)

Article Cardiac & Cardiovascular Systems

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Andrew P. Landstrom et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)

Article Biochemistry & Molecular Biology

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

Sho Kakizawa et al.

EMBO JOURNAL (2007)

Article Cell Biology

T-tubule formation in cardiacmyocytes:: two possible mechanisms?

Alessandro Di Maio et al.

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2007)

Article Multidisciplinary Sciences

Graded regulation of the Kv2.1 potassium channel by variable phosphorylation

Kang-Sik Park et al.

SCIENCE (2006)

Article Cell Biology

Kv2 channels oppose myogenic constriction of rat cerebral arteries

Gregory C. Amberg et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

Article Multidisciplinary Sciences

Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins

Shigeki Moriguchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cell Biology

Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery

V Di Biase et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Neurosciences

Regulation of ion channel localization and phosphorylation by neuronal activity

H Misonou et al.

NATURE NEUROSCIENCE (2004)

Article Cardiac & Cardiovascular Systems

Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries

S Earley et al.

CIRCULATION RESEARCH (2004)

Article Neurosciences

Coexpression of junctophilin type 3 and type 4 in brain

M Nishi et al.

MOLECULAR BRAIN RESEARCH (2003)

Article Biochemistry & Molecular Biology

IP3-dependent calcium-induced calcium release mediates bidirectional calcium waves in neurones:: functional implications for synaptic plasticity

JG Barbara

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2002)

Article Multidisciplinary Sciences

Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle

EY Lee et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1

S Komazaki et al.

FEBS LETTERS (2002)

Article Biochemistry & Molecular Biology

Motor discoordination in mutant mice lacking junctophilin type 3

M Nishi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Cell Biology

Voltage dependence of the coupling of Ca2+ sparks to BKCa channels in urinary bladder smooth muscle

GM Herrera et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Physiology

Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca2+ channel

G Avila et al.

JOURNAL OF GENERAL PHYSIOLOGY (2000)