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Regulation of Host-Pathogen Interactions via the Ubiquitin System

期刊

ANNUAL REVIEW OF MICROBIOLOGY
卷 76, 期 -, 页码 211-233

出版社

ANNUAL REVIEWS
DOI: 10.1146/annurev-micro-041020-025803

关键词

ubiquitin; host-pathogen interactions; bacterial effectors; organelle remodeling

资金

  1. Deutsche Forschungsgemeinschaft (DFG
  2. German Research Foundation) [259130777-SFB 1177]
  3. European Research Council (ERC) under the European Union [742720]
  4. Else Kroner Fresenius Stiftung
  5. Dr. Rolf M. Schwiete Stiftung
  6. Ernst Jung Prize for Medicine
  7. Alexander von Humboldt Stiftung postdoctoral fellowship

向作者/读者索取更多资源

Ubiquitination is an important posttranslational modification that regulates cellular functions. Pathogens have evolved mechanisms to evade or counteract host responses regulated by ubiquitin, and even exploit the ubiquitin system for their own benefit. Host cellular signaling networks undergo significant changes upon pathogen attack to protect the cell and limit pathogen growth. Mechanistic insights into ubiquitin regulation of host-pathogen interactions provide valuable information on bacterial and viral pathogenesis and host cell organization and response.
Ubiquitination is a posttranslational modification that regulates a multitude of cellular functions. Pathogens, such as bacteria and viruses, have evolved sophisticated mechanisms that evade or counteract ubiquitin-dependent host responses, or even exploit the ubiquitin system to their own advantage. This is largely done by numerous pathogen virulence factors that encode E3 ligases and deubiquitinases, which are often used as weapons in pathogen-host cell interactions. Moreover, upon pathogen attack, host cellular signaling networks undergo major ubiquitin-dependent changes to protect the host cell, including coordination of innate immunity, remodeling of cellular organelles, reorganization of the cytoskeleton, and reprogramming of metabolic pathways to restrict growth of the pathogen. Here we provide mechanistic insights into ubiquitin regulation of host-pathogen interactions and how it affects bacterial and viral pathogenesis and the organization and response of the host cell.

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