PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes

Article Medicine, Research & Experimental

MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes

Jiajie Tu et al.

Summary: miR-10b disrupts the balance of CD4(+) T cell subsets and promotes the progression of rheumatoid arthritis (RA). Inhibiting miR-10b can alleviate the severity of arthritis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Review Biochemistry & Molecular Biology

Innate immunity drives pathogenesis of rheumatoid arthritis

Maria Edilova et al.

Summary: Rheumatoid arthritis is an autoimmune disease affecting about 1% of the population, with genetic and environmental factors playing key roles in its pathogenesis. While early studies focused on lymphocytes, recent research has highlighted the critical involvement of innate immune cells in the onset and progression of RA. Therapeutic approaches targeting different inflammatory pathways and immune cells, including the emerging roles of innate lymphoid cells and inflammasomes, are being explored for the treatment of RA.

BIOMEDICAL JOURNAL (2021)

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Review Biotechnology & Applied Microbiology

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

Dennis S. W. Lee et al.

Summary: B cells have been found to actively participate in autoimmune diseases, leading to the clinical success of B cell depletion therapies like those targeting CD20, CD19, and BAFF. Despite limited impact on antibody levels and plasma cells in controlling the disease, research on B cells is constantly evolving and developing.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Immunology

A Tale of Two Immune Cells in Rheumatoid Arthritis: The Crosstalk Between Macrophages and T Cells in the Synovium

Jiajie Tu et al.

Summary: RA is a chronic inflammatory autoimmune disease characterized by joint inflammation, immune cell infiltration, synovial hyperplasia, and excessive production of proinflammatory cytokines. The interaction between monocytes/macrophages and T cells in the joint synovium of RA patients plays a crucial role in promoting the development of RA. Further understanding of these interactions may lead to new perspectives on RA pathogenesis and targeted therapy development.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

How transcription factors drive choice of the T cell fate

Hiroyuki Hosokawa et al.

Summary: Transcription factors play essential roles in early thymic development to establish T cell lineage identity by controlling the activities of specific genomic loci. The interactions between inherited epigenetic states, transcription factor-DNA binding affinity thresholds, and influences of given transcription factors on other factors in the same cells determine T cell identity and make the lineage choice irreversible.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology