☆ 4.4 Article

Pharmacokinetic and pharmacodynamic comparison of epinephrine, administered intranasally and intramuscularly An integrated analysis

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2023)

Pharmacokinetics of adrenaline autoinjectors

Paul J. Turner et al.

Summary: Anaphylaxis is a medical emergency where adrenaline is the first-line therapy. Pharmacokinetic data for autoinjector devices show that injection force and speed may be more important than needle length. Different devices result in varying plasma adrenaline profiles.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

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Article Allergy

Accidental Intravascular Auto-Injection of Epinephrine (Adrenaline) Rapidly Increases Pharmacokinetic and Hemodynamic Parameters

Motohiro Ebisawa et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

EAACI guideline: Anaphylaxis (2021 update)

Antonella Muraro et al.

Summary: The updated guideline on anaphylaxis emphasizes early recognition and prompt use of intramuscular adrenaline as first-line management. It also recommends comprehensive training for people at risk of anaphylaxis and improving healthcare professionals' management skills. Additionally, the urgent need for clinical trials to improve patient management in anaphylaxis is highlighted.

ALLERGY (2022)

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Review Allergy