Dasatinib-induced follicular lymphoid hyperplasia, an entity to know

Follicular lymphoid hyperplasia induced by dasatinib is an entity recently described. It is sometimes difficult to rule out the diagnostic of small B-cell lymphoma. Usually, the node is swollen, with follicular architecture conserved, composed by germinal centers with variable size and shape, with a hight number of mitoses and tingible bodies macrophages inside. Follicular lymphoid hyperplasia is isolated or associated with multiple reactive patterns. The immunohistochemical profil of germinal centers is CD20+, CD10+, BCL6+, BCL2-. Swollen node disappears in a short time after dasatinib discontinuation. Clinicians and pathologists need to be aware of this entity, so as not to avoid mistakenly suspect lymphoma when lymphadenopathy occurs in a patient with chronic myeloid leukemia treated with dasatinib. (c) 2022 Elsevier Masson SAS. All rights reserved.

Automated summary

Follicular lymphoid hyperplasia induced by dasatinib is a recently described entity that is sometimes difficult to distinguish from small B-cell lymphoma. It is characterized by swollen lymph nodes with preserved follicular architecture, germinal centers with varied size and shape, a high number of mitoses, and tingible bodies macrophages. Follicular lymphoid hyperplasia can occur alone or in association with multiple reactive patterns. The immunohistochemical profile of germinal centers is CD20+, CD10+, BCL6+, BCL2-. Swollen lymph nodes disappear shortly after discontinuation of dasatinib. Clinicians and pathologists should be aware of this entity to avoid mistakenly suspecting lymphoma in patients with chronic myeloid leukemia treated with dasatinib. (c) 2022 Elsevier Masson SAS. All rights reserved.