期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 39, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202207484
关键词
cocrystals; crystal engineering; drug discovery; pharmaceutical development; supramolecular synthons
资金
- University Grants Commission
- Department of Science and Technology
- SERB [SR/S2/JCB-06/2009, CRG/2019/001388]
- Institute of Eminence status for UoH (Ministry of Education)
Based on a molecular pharmacophore, this study suggests that the heterosynthon, a supramolecular synthon between different functional groups, plays a similar role in the design and discovery of high bioavailability drugs. The heterosynthon could offer a more efficient and cost-effective route for novel drug development.
Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.
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