4.8 Article

Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability

期刊

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202207484

关键词

cocrystals; crystal engineering; drug discovery; pharmaceutical development; supramolecular synthons

资金

  1. University Grants Commission
  2. Department of Science and Technology
  3. SERB [SR/S2/JCB-06/2009, CRG/2019/001388]
  4. Institute of Eminence status for UoH (Ministry of Education)

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Based on a molecular pharmacophore, this study suggests that the heterosynthon, a supramolecular synthon between different functional groups, plays a similar role in the design and discovery of high bioavailability drugs. The heterosynthon could offer a more efficient and cost-effective route for novel drug development.
Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.

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