Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability

Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.

Automated summary

Based on a molecular pharmacophore, this study suggests that the heterosynthon, a supramolecular synthon between different functional groups, plays a similar role in the design and discovery of high bioavailability drugs. The heterosynthon could offer a more efficient and cost-effective route for novel drug development.