期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 44, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202211081
关键词
Aza-BODIPY Dimer; Exciton Coupling; J-Type Aggregates; Photothermal Therapy
资金
- National Nature Science Foundation of China [21871006, 21971004]
- Anhui Provincial Natural Science Foundation [2108085QB81]
- University Synergy Innovation Program of Anhui Province [GXXT-2020-074]
- University of Science and Technology of China
In this study, we developed ethene-bridged aza-BODIPY dimers with intramolecular exciton splitting and produced J-type aggregated nanoparticles by encapsulating the dimers into F-127 polymer. The nanoparticles showed obvious intermolecular exciton coupling and redshifted absorption and emission peaks. The fabricated nanoagents exhibited high photothermal conversion ability and photostability, leading to complete tumor ablation through laser irradiation.
Spatial electronic communications of chromophores are both theoretically and practically fascinating. Despite intramolecular or intermolecular exciton coupling was observed in multichromophoric oligomers and J-aggregates, respectively, it is unusual that they both occur in the same molecule. Herein, ethene-bridged aza-BODIPY dimers with intramolecular exciton splitting have been developed. By encapsulating the dimer into F-127 polymer, J-type aggregated nanoparticles were produced, which showed obvious intermolecular exciton coupling and dramatically redshifted absorption and emission peaks at 936 and 1003 nm, respectively. The fabricated nanoagents have high photothermal conversion ability (eta=60.3 %) and are ultra-photostable, leading to complete tumor ablation with 915 nm laser irradiation. This phototherapeutic nanoplatform through modulating both intra- and intermolecular exciton couplings is a valuable paradigm for developing photothermal agents for tumor treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据