Nickel-Catalyzed Site-Selective Intermolecular C(sp3)-H Amidation

A nickel-catalyzed site-selective intermolecular amidation of saturated C(sp(3))-H bonds is reported. This mild protocol exhibits a predictable reactivity pattern to incorporate amide functions at C(sp(3))-H sites adjacent to nitrogen and oxygen atoms in either cyclic or acyclic frameworks, thus offering a complementary reactivity profile to existing oxidative-type processes or metal-catalyzed C(sp(3))-N bond-forming reactions operating via two-electron manifolds.

Automated summary

A nickel-catalyzed site-selective intermolecular amidation of saturated C(sp(3))-H bonds has been reported, allowing for the introduction of amide functionalities at specific sites. This method exhibits a predictable reactivity pattern, offering a complementary reactivity profile to existing oxidative processes or metal-catalyzed C(sp(3))-N bond-forming reactions.