期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 61, 期 42, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202210214
关键词
Heteropolymer; Ion Channel; K+ Selectivity; Membrane Anchor; pH-Gated
资金
- National Natural Science Foundation of China [22161142015, 22105056]
- National Key R&D Program of China [2020YFA0907003, 2020YFA0908501]
- Scientific Research Start-up Foundation of Hangzhou Normal University [2019QDL026]
Artificial ion channels derived from single-chain random heteropolymers (RHPs) with high selectivity and controllable gating behavior have been successfully fabricated. Chemically designed to transport K+ over Na+, these channels exhibit switchable characteristics similar to natural gated protein channels. This work provides insights for future design of novel functional nanochannels.
A series of single-chain random heteropolymer (RHP)-derived artificial ion channels with both high K+ selectivity and controllable pH-gated behaviors were fabricated by a facile one-pot polymerization method. The benzo-18-crown-6 moieties appended on lateral chains of RHPs can form ion-permeable nanopores and transport K+ over Na+ through the lipid bilayers. The ion permeation selectivity was significantly enhanced by incorporating a cholesterol group to serve as a membrane anchor. Interestingly, similar to natural gated protein channels, on-off switchable characteristics were also realized by integrating an additional acid-sensitive alkylamine group into the RHP-derived channel. The unique design strategies have endowed the RHP-derived ion channels with facile synthetic procedures, desirable membrane compatibility, high K+ selectivity, and tunable pH-gated properties. This work provides an entry point for future design of novel functional nanochannels.
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