期刊
ANALYTICAL CHEMISTRY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c02911
关键词
-
资金
- NNSF of China
- Chongqing Postdoctoral Innovative Talent Support Program
- [22174113]
- [22176153]
- [21974108]
- [7820100788]
Pt@tetraphenyl-1,3-butadiene nanocrystals (Pt@TPB NCs) with high electrochemiluminescence (ECL) efficiencies were developed for ultrasensitive biosensing of microRNA-21 (miRNA-21). The Pt@TPB NCs not only exhibited high ECL emission but also served as coreaction accelerators for generating reactive oxygen species (ROS), resulting in intense ECL emission. The use of Pt@TPB NCs as ECL emitters enabled ultrasensitive detection of miRNA-21.
Herein, Pt@tetraphenyl-1,3-butadiene nanocrystals (Pt@TPB NCs) with high electrochemiluminescence (ECL) efficiencies as ECL emitters were developed to construct an ultrasensitive biosensing platform for the detection of microRNA-21 (miRNA-21). Interestingly, Pt@TPB NCs not only exhibited high carrier densities and electron mobilities to achieve efficient electron- hole pair recombinations for high ECL emission but also served as coreaction accelerators of endogenous coreactant-dissolved O2 with good electrocatalytic activities to produce abundant reactive oxygen species (ROS) for facilitating the interactions between TPB NCs and ROS, which further obtain intense ECL emission. Impressively, Pt@TPB NCs with dissolved O2 as coreactants displayed high ECL efficiencies (phi ECL) of 7.83, taking the phi ECL of Ru(bpy)32+/dissolved O2 ECL system as 1. Herein, Pt@TPB NCs with strong ECL signals were used as ECL emitters to combine target-induced DNA walker amplification with high conversion efficiency for the construction of an ultrasensitive ECL biosening platform which accomplished microRNA-21 detection with a low detection limit of 83.8 aM. Therefore, the developed synergy effects in Pt@TPB NCs are expected to guide the progress of highly efficient ECL emitters for sensing analysis and disease diagnosis.
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