期刊
ANALYTICAL CHEMISTRY
卷 94, 期 36, 页码 12383-12390出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.2c01972
关键词
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资金
- Natural Science Foundation of Zhejiang Province [LQ21B050001, LY20B010003]
- National Natural Science Foundation of China [21801054]
- Foundation of Wenzhou Basic Scientific Research Project [Y20210265]
Tracking liver polarity using noninvasive and dynamic imaging techniques is crucial for understanding non-alcoholic fatty liver (NAFL). A novel near-infrared fluorescent probe called Cy-Mp was developed, which emits at NIR wavelengths with high photostability and a large Stokes shift. Cy-Mp exhibits a ratiometric response to polarity, enabling accurate analysis of intracellular polarity. In vivo studies demonstrated that Cy-Mp can accumulate in the liver and diagnose NAFL by detecting decreased polarity.
Tracking liver polarity with noninvasive and dynamic imaging techniques is helpful to better understand the non-alcoholic fatty liver (NAFL). Herein, a novel near-infrared (NIR) fluorescent probe Cy-Mp is constructed using a symmetry collapse strategy. The structure modification leads to the conversion of locally excited state fluorescence to charge transfer state fluorescence. Cy-Mp emits at near-infrared (NIR) wavelengths with high photostability as well as a large Stokes shift. Cy-Mp exhibits a ratiometric response to polarity, providing more accurate analysis of intracellular polarity via the built-in internal reference correction. Most importantly, the in vivo studies indicate that Cy-Mp can accumulate in the liver and the decreased polarity in the liver of mice with NAFL is verified by the ratiometric imaging, implying the great potential of Cy-Mp in the diagnosis of NAFL.
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