期刊
ANALYTICA CHIMICA ACTA
卷 1234, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aca.2022.340512
关键词
Glycan enrichment; 2D nanomaterial; Nanotechnology; Glycomics
资金
- Innovative Training Network [813120]
- Ministry of Health of the Slovak Republic [2019/7-CHUSAV-4, 2019/68-CHUSAV-1]
- Operational Program Integrated Infrastructure [ITMS: 313011V578]
- European Regional Development Fund [ITMS: 313011V578]
- Slovak Research and Development Agency [APVV-20-0272]
- Qatar University [QUCG-CAM-22/23-504]
In this study, MXene was used as a column cartridge for N-glycan enrichment from human samples, with a focus on the analysis of sialic acid linkages. The MXene-based cartridge enriched a higher number of glycans compared to commercial HILIC columns. This study demonstrates the strong potential of MXene as a stationary phase in MS glycomic analysis.
In this study, we applied MXene as column cartridge for N-glycan enrichment from human samples with a focus on the analysis of sialic acid linkages using a derivatisation protocol followed by glycan analysis via Matrix Assisted Laser Desorption Ionisation-Time Of Flight Mass Spectrometry (MALDI-TOF-MS). The MXene-based cartridge enriches a higher number of glycans (i.e., sialylated and bisecting N-glycans) when compared to the commercial HILIC columns. We demonstrate the strong potential of MXene as a stationary phase in MS glycomic analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据