Polymorphisms and Severity of COVID-19 Reply

Article Genetics & Heredity

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

Jennifer E. Huffman et al.

Summary: The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype derived from Neanderthals. The splice variant of OAS1 is found in individuals of African ancestry independently, and it is likely responsible for the association with COVID-19 severity.

NATURE GENETICS (2022)

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Article Medicine, General & Internal

APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

Adriana M. Hung et al.

Summary: This study found that the risk group with two APOL1 high-risk genetic variants (G1 or G2) in individuals of African ancestry have a higher risk of developing COVID-19-associated AKI and death.

JAMA INTERNAL MEDICINE (2022)

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Article Genetics & Heredity

Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program

Gina M. Peloso et al.

Summary: This study conducted a genetic analysis of COVID-19 cases in a large biobank and identified several genetic variants associated with COVID-19 positivity, including a novel locus found exclusively among Hispanics. The study also extended previous findings to include Black and Hispanic individuals. These findings are important for discovering new therapeutic agents to reduce the morbidity and mortality of COVID-19.

FRONTIERS IN GENETICS (2022)

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Article Genetics & Heredity

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

Anurag Verma et al.

Summary: This study explores the shared genetic architecture between COVID-19 severity and existing medical conditions through a genome-wide association study. The findings indicate that certain genetic variants are associated with both the severity of COVID-19 and reduced risk of immune-mediated diseases. Differences in genotype-phenotype associations across ancestries may contribute to the heterogeneity of COVID-19 outcomes. The divergent associations between risk for severe COVID-19 and autoimmune inflammatory conditions highlight the shared pathways and caution needed when considering treatment targets.

PLOS GENETICS (2022)

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Article Critical Care Medicine

A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality

Anurag Verma et al.

Summary: The MUC5B gene polymorphism rs35705950-T is associated with reduced risk of hospitalization and post-COVID-19 pneumonia in individuals of European ancestry, according to a study involving participants in the Million Veteran Program (MVP).

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Medicine, General & Internal

Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait

Anurag Verma et al.

Summary: This genetic association study indicates that sickle cell trait (SCT) is associated with preexisting kidney comorbidities, increased COVID-19 mortality, and kidney morbidity.

JAMA INTERNAL MEDICINE (2022)

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Polymorphisms and Severity of COVID-19 Reply

相关参考文献

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality

Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait

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