4.7 Review

Chronic obstructive pulmonary disease and the modulation of CFTR by acute exposure to cigarette smoke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Critical Care Medicine

Cystic Fibrosis Transmembrane Conductance Regulator: Roles in Chronic Obstructive Pulmonary Disease

Mark Dransfield et al.

Summary: Chronic obstructive pulmonary disease (COPD) is a complex disease with various clinical presentations. Current treatment focuses on symptom relief and prevention of complications, tailored to disease severity. Chronic inflammation and mucus hypersecretion are key features of COPD. Recent research suggests similarities between COPD and cystic fibrosis (CF), with dysfunction of CFTR playing a role in both diseases.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Respiratory System

Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction

Niroop Kaza et al.

Summary: This study aimed to evaluate CFTR dysfunction induced by smoking and test the pharmacological reversal of CFTR dysfunction using a novel CFTR potentiator, GLPG2196, in a ferret model of COPD with chronic bronchitis. The results showed that GLPG2196 treatment reversed CFTR dysfunction and improved pathological features.

EUROPEAN RESPIRATORY JOURNAL (2022)

Article Cell Biology

Edaravone Attenuated Particulate Matter-Induced Lung Inflammation by Inhibiting ROS-NF-κB Signaling Pathway

Yingying Zeng et al.

Summary: The study demonstrated that EDA treatment has a protective effect on alleviating PM-induced lung inflammation by maintaining mitochondrial balance and regulating the ROS-NF-kappa B p65 signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Review Critical Care Medicine

Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis

Davies Adeloye et al.

Summary: This study aimed to estimate the prevalence and risk factors of chronic obstructive pulmonary disease (COPD) globally, regionally, and nationally, in order to guide policy and population interventions.

LANCET RESPIRATORY MEDICINE (2022)

Review Respiratory System

Role of unfolded proteins in lung disease

Kirsty L. Bradley et al.

Summary: The lungs are exposed to various environmental toxins and pathogens, leading to respiratory diseases associated with hypoxia. Endoplasmic reticulum stress can be triggered by these factors, activating the unfolded protein response. This response plays a significant role in the pathogenesis and progression of respiratory diseases, making it a potential target for therapeutic interventions.

THORAX (2021)

Article Physiology

The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress

Necola Guerrina et al.

Summary: The aryl hydrocarbon receptor (AhR) plays a crucial role in protecting cells from apoptosis induced by tobacco smoke, but its role in protecting cells from autophagy or ER stress is not well understood. Using CSE as a surrogate for tobacco exposure, researchers found a novel role for AhR in attenuating ER stress through a potential autophagy-independent mechanism in lung structural cells.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

Article Critical Care Medicine

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia

Kenichi Okuda et al.

Summary: The study revealed that secretory cells dominate CFTR expression and function in human airway superficial epithelia, suggesting that CFTR therapies may need to restore CFTR function to multiple cell types, with a focus on secretory cells.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Multidisciplinary Sciences

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Jenny P. Nguyen et al.

Summary: The study found that modulation of cAMP, in combination with CFTR modulator VX-770, can increase CFTR activity, potentially serving as an add-on therapy for the optimal management of CF disease. The results suggest that combinatorial therapy of cAMP modulation with ABCC4 and PDE-4 inhibitors has potential in increasing CFTR activity.

SCIENTIFIC REPORTS (2021)

Article Environmental Sciences

An Unrecognized Hazard in E-Cigarette Vapor: Preliminary Quantification of Methylglyoxal Formation from Propylene Glycol in E-Cigarettes

Parham Azimi et al.

Summary: Propylene glycol in e-cigarettes can generate harmful substances such as diacetyl and methylglyoxal. Recent research shows that methylglyoxal is more toxic to epithelial cells, raising urgent public health concerns.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Immunology

Large pH oscillations promote host defense against human airways infection

Dusik Kim et al.

Summary: The airway surface undergoes large pH excursions during breathing, reaching pH 9.0 during inhalation. Reduced luminal bicarbonate and CA12 expression in cystic fibrosis lead to impaired bacterial-killing efficacy. Defective pH oscillations may compromise airway host defense in other respiratory diseases.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Multidisciplinary Sciences

Necroptosis activates UPR sensors without disrupting their binding with GRP78

Wei Liang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium

Yukiko Sato et al.

Summary: Evidence suggests that CFTR anion channel is highly expressed in ciliated cells of human bronchial epithelium (HBE), despite low levels of CFTR mRNA detected in these cells. Immunostaining and imaging techniques revealed apical immunofluorescence patterns in ciliated cells, with a correlation between CFTR antibodies and ciliary protein rootletin X1 expression levels. This may explain anomalous apical immunofluorescence in well-differentiated cells expressing F508del-CFTR.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies

Caspar Schiffers et al.

Summary: With the aging population, the incidence of age-related lung diseases like COPD is increasing, although antioxidant supplementation strategies have had limited success in mitigating disease progression. Reactive oxygen species are believed to play a crucial role in aging, and the role of NADPH oxidase enzymes in age-related lung diseases remains largely unexplored.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Dysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicine

Laura Carrasco-Hernandez et al.

Summary: The role of CFTR in the pathophysiology of COPD is becoming increasingly important, with its dysfunction leading to thicker and more viscous secretions in the airway, reduced mucociliary clearance, and promotion of airway inflammation. Studying CFTR in the context of COPD pathogenesis is crucial for a comprehensive understanding of COPD's complex pathophysiology and exploring potential therapeutic approaches to address this dysfunction.

BIOMEDICINES (2021)

Article Biochemistry & Molecular Biology

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

Gianni Carraro et al.

Summary: Single-cell RNA profiling of human cystic fibrosis proximal airway tissue shows an abundance of epithelial cells transitioning to specialized ciliated and secretory cells, coupled with a decrease in cycling basal cells. The study provides insights into disease-related changes and offers potential for the development of new targeted therapies for cystic fibrosis airway disease.

NATURE MEDICINE (2021)

Article Environmental Sciences

Cigarette Smoke Extract Produces Superoxide in Aqueous Media by Reacting with Bicarbonate

Jung-Min Park et al.

Summary: The presence of bicarbonate in the experimental conditions influences the superoxide generation induced by cigarette smoke, with peroxidase treatment reducing more than half of the superoxide production. This suggests that peroxides and peroxy acids are the main contributors to superoxide production in this process.

TOXICS (2021)

Article Critical Care Medicine

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease

Zhe Lu et al.

Summary: This study found that necroptosis is increased in patients with chronic obstructive pulmonary disease (COPD) and in experimental COPD, and inhibiting necroptosis can alleviate smoking-induced airway inflammation, airway remodeling, and emphysema. Deletion of Ripk3 or Mlkl and treatment with qVD-OPh can reduce lung cell death induced by chronic smoking exposure.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Article Chemistry, Medicinal

Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

Darren Le Grand et al.

Summary: Mutations in the CFTR ion channel are linked to cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). A potential drug, icenticaftor (QBW251), has shown positive clinical results for CF and COPD patients. This study provides insights into the pathogenesis of these lung diseases and offers a novel therapeutic approach for COPD patients.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Cyclic nucleotide phosphodiesterase inhibitors as therapeutic interventions for cystic fibrosis

Mark J. Turner et al.

Summary: Cystic Fibrosis (CF) lung disease is caused by mutations in the CFTR gene that affect anion and fluid secretion. Studying members of the PDE family regulating CFTR-dependent secretion and the effects of PDE inhibitors on cyclic nucleotide-regulated functions.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Physiology

Epithelial Barrier Dysfunction in Chronic Respiratory Diseases

Francois M. Carlier et al.

Summary: Mucosal surfaces are protected by epithelial cells, which form a complex module to defend against external threats such as toxins and pathogens. Chronic diseases can disrupt the function of the epithelial barrier, leading to impaired protection. Understanding the mechanisms behind epithelial barrier abnormalities is crucial for future therapeutic approaches.

FRONTIERS IN PHYSIOLOGY (2021)

Review Respiratory System

Inhaled Dual Phosphodiesterase 3/4 Inhibitors for the Treatment of Patients with COPD: A Short Review

Clennence Martin et al.

Summary: Current pharmacological treatments for COPD are limited to inhaled bronchodilators and corticosteroids, but azithromycin and oral PDE4 inhibitors like roflumilast can prevent exacerbations. Inhaled dual PDE3/4 inhibitors have been developed to enhance bronchodilation and modulate inflammation, with RPL554/ensifentrine showing promising results in clinical trials. Ongoing Phase III studies are needed to confirm its beneficial effects and safety profile on a larger scale.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

Article Genetics & Heredity

Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

Mahboubeh R. Rostami et al.

Summary: This study identified subpopulations of club cells with distinct functions in healthy nonsmokers and healthy cigarette smokers, including progenitor, proliferating, and effector club cells. Smoking was found to limit differentiation of these subclusters and alter club cell function, providing insights into smoking-induced changes in club cell biology.

NPJ GENOMIC MEDICINE (2021)

Review Biochemistry & Molecular Biology

Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPD

Hirofumi Kiyokawa et al.

Summary: Epithelial cells in the respiratory system are directly exposed to exogenous ROS, increasing the risk of oxidative stress; Dysfunction of redox regulation due to cellular aging accelerates COPD pathogenesis; Drugs targeting oxidative stress pathways can help precisely regulate the redox system.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

Stefano Bestetti et al.

REDOX BIOLOGY (2020)

Article Multidisciplinary Sciences

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

Katherine C. Goldfarbmuren et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Oxidative stress-based therapeutics in COPD

Peter J. Barnes

REDOX BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress and glutathione therapeutics in chronic lung diseases

Yvonne Janssen-Heininger et al.

REDOX BIOLOGY (2020)

Article Respiratory System

CFTR targeted therapies: recent advances in cystic fibrosis and possibilities in other diseases of the airways

Sheylan D. Patel et al.

EUROPEAN RESPIRATORY REVIEW (2020)

Article Pharmacology & Pharmacy

Airway Mucins Inhibit Oxidative and Non-Oxidative Bacterial Killing by Human Neutrophils

Andre M. Cantin et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Respiratory System

Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial

Steven M. Rowe et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

Review Medicine, General & Internal

Diagnosis and Treatment of Early Chronic Obstructive Lung Disease (COPD)

Joon Young Choi et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications

Aitor Almanza et al.

FEBS JOURNAL (2019)

Article Biochemistry & Molecular Biology

HDAC inhibitors rescue multiple disease-causing CFTR variants

Frederic Angles et al.

HUMAN MOLECULAR GENETICS (2019)

Article Gastroenterology & Hepatology

AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species

Stephanie J. King et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

Article Physiology

Cigarette and ENDS preparations differentially regulate ion channels an mucociliary clearance in primary normal human bronchial 3D cultures

Rachael E. Rayner et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress

Daniel S. Aridgides et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum

Abigail J. Marklew et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Vaporized E-Cigarette Liquids Induce Ion Transport Dysfunction in Airway Epithelia

Vivian Y. Lin et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Increases in cytosolic Ca2+ induce dynamin- and calcineurin-dependent internalisation of CFTR

Waseema Patel et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Physiology

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

Laszlo Csanady et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Pendrin Mediates Bicarbonate Secretion and Enhances Cystic Fibrosis Transmembrane Conductance Regulator Function in Airway Surface Epithelia

Dusik Kim et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Article Cell Biology

Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells

Francis H. Wong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

Article Critical Care Medicine

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci

Jarrett D. Morrow et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Critical Care Medicine

Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity

Deepika Polineni et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Biochemistry & Molecular Biology

The psychoactive substance of cannabis Δ9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells

Sheng-Wei Chang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Article Pharmacology & Pharmacy

Cigarette smoke up-regulates PDE3 and PDE4 to decrease cAMP in airway cells

Haoxiao Zuo et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Cell Biology

Airway Epithelium Dysfunction in Cystic Fibrosis and COPD

Virginia De Rose et al.

MEDIATORS OF INFLAMMATION (2018)

Article Cell Biology

Impact of acute exposure to cigarette smoke on airway gene expression

E. Billatos et al.

PHYSIOLOGICAL GENOMICS (2018)

Article Multidisciplinary Sciences

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

Lindsey W. Plasschaert et al.

NATURE (2018)

Article Multidisciplinary Sciences

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Daniel T. Montoro et al.

NATURE (2018)

Article Medicine, Research & Experimental

Chronic β2AR stimulation limits CFTR activation in human airway epithelia

John J. Brewington et al.

JCI INSIGHT (2018)

Article Chemistry, Multidisciplinary

Rate of Lipid Peroxyl Radical Production during Cellular Homeostasis Unraveled via Fluorescence Imaging

Lana E. Greene et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Cell Biology

Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury

Yi-Ping Hu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

Synergy of cAMP and calcium signaling pathways in CFTR regulation

Zoltan Bozoky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Medicine, General & Internal

Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms

Adam John Anthony McGuinness et al.

JOURNAL OF CLINICAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

Potential sites of CFTR activation by tyrosine kinases

Arnaud Billeta et al.

CHANNELS (2016)

Article Biochemistry & Molecular Biology

DNA methylation profiling in human lung tissue identifies genes associated with COPD

Jarrett D. Morrow et al.

EPIGENETICS (2016)

Review Biology

Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma

Krishna Samanta et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2016)

Article Biochemistry & Molecular Biology

Cigarette smoke extract is a Nox agonist and regulates ENaC in alveolar type 2 cells

Charles A. Downs et al.

AIMS MOLECULAR SCIENCE (2016)

Article Biochemistry & Molecular Biology

Oxidative Stress Regulates CFTR Gene Expression in Human Airway Epithelial Cells through a Distal Antioxidant Response Element

Zhaolin Zhang et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Article Cell Biology

Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34

Yang Sun et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Review Physiology

AIRWAY GLAND STRUCTURE AND FUNCTION

Jonathan H. Widdicombe et al.

PHYSIOLOGICAL REVIEWS (2015)

Article Multidisciplinary Sciences

Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface

Andrea C. Schamberger et al.

SCIENTIFIC REPORTS (2015)

Article Respiratory System

Roflumilast partially reverses smoke-induced mucociliary dysfunction

Andreas Schmid et al.

RESPIRATORY RESEARCH (2015)

Review Respiratory System

Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis

Mario Cazzola et al.

EUROPEAN RESPIRATORY REVIEW (2015)

Article Physiology

Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes

A. R. Moran et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis

James A. Lambert et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Pharmacology & Pharmacy

Dual PDE3/4 and PDE4 Inhibitors: Novel Treatments For COPD and Other Inflammatory Airway Diseases

Katharine H. Abbott-Banner et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

Review Biochemistry & Molecular Biology

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

Gerd P. Bienert et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Respiratory System

Analysis of the Plasma Proteome in COPD: Novel Low Abundance Proteins Reflect the Severity of Lung Remodeling

Salim Merali et al.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2014)

Article Biochemistry & Molecular Biology

Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP

F. Romana Auciello et al.

FEBS LETTERS (2014)

Review Biochemistry & Molecular Biology

Redox balance in Cystic Fibrosis

Assem G. Ziady et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

Simao Luz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Cigarette Smoke-induced Ca2+ Release Leads to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction

Julia E. Rasmussen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

A Simple and Rapid Method for Standard Preparation of Gas Phase Extract of Cigarette Smoke

Tsunehito Higashi et al.

PLOS ONE (2014)

Review Physiology

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

Andras Rab et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Article Critical Care Medicine

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

S. Vamsee Raju et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Biochemistry & Molecular Biology

H2O2 Stimulates Cystic Fibrosis Transmembrane Conductance Regulator through an Autocrine Prostaglandin Pathway, Using Multidrug-Resistant Protein-4

Gregory E. Conner et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Review Pharmacology & Pharmacy

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling

Stefania Monterisi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Critical Care Medicine

Oxidative Stress in COPD

Paul A. Kirkham et al.

Review Pathology

A review of in vitro cigarette smoke exposure systems

David Thorne et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2013)

Article Biochemistry & Molecular Biology

Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Arnaud Billet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Neurosciences

The secret life of CFTR as a calcium-activated chloride channel

Arnaud Billet et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Article Medicine, Research & Experimental

Cigarette Smoke-Induced Proteostasis Imbalance in Obstructive Lung Diseases

A. M. Cantin et al.

CURRENT MOLECULAR MEDICINE (2012)

Article Medicine, Research & Experimental

Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein

Nathan S. Alexander et al.

LARYNGOSCOPE (2012)

Article Pharmacology & Pharmacy

The Prostaglandin E2 Type 4 Receptor Participates in the Response to Acute Oxidant Stress in Airway Epithelial Cells

Christina L. Jones et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Review Biochemistry & Molecular Biology

Cigarette smoking, cyclooxygenase-2 pathway and cancer

Run-Yue Huang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2011)

Review Chemistry, Multidisciplinary

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Huiyong Yin et al.

CHEMICAL REVIEWS (2011)

Article Physiology

Massive calcium-activated endocytosis without involvement of classical endocytic proteins

Vincenzo Lariccia et al.

JOURNAL OF GENERAL PHYSIOLOGY (2011)

Review Cell Biology

Role of epithelial HCO3- transport in mucin secretion: lessons from cystic fibrosis

Paul M. Quinton

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Editorial Material Biochemistry & Molecular Biology

Protein Carbonylation

Yuichiro J. Suzuki et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Article Respiratory System

Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT® trial

T. Troosters et al.

EUROPEAN RESPIRATORY JOURNAL (2010)

Article Medicine, Research & Experimental

cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways

Robert J. Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy

Nadzeya V. Marozkina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

Evan W. Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Physiology

Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells

Marco van der Toorn et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Editorial Material Critical Care Medicine

Oxidants Are Not All Created Equal Could Hydrogen Peroxide Actually Be Good for Our Lungs?

Yvonne M. W. Janssen-Heininger et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

Article Chemistry, Medicinal

Effects of Mainstream Cigarette Smoke on the Global Metabolome of Human Lung Epithelial Cells

Suryanarayana V. Vulimiri et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2009)

Article Biochemistry & Molecular Biology

Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells

Sonia Eligini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

Mechanistic Insight into Control of CFTR by AMPK

Patthara Kongsuphol et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Medicine, General & Internal

Chronic obstructive pulmonary disease in non-smokers

Sundeep S. Salvi et al.

LANCET (2009)

Article Medicine, Research & Experimental

Cigarette Smoke Condensate Inhibits Transepithelial Chloride Transport and Ciliary Beat Frequency

Noam A. Cohen et al.

LARYNGOSCOPE (2009)

Article Cell Biology

Store-operated cyclic AMP signalling mediated by STIM1

Konstantinos Lefkimmiatis et al.

NATURE CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases

Yanping Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Respiratory System

Persistence of oxidant and protease burden in the airways after smoking cessation

Noora Louhelainen et al.

BMC Pulmonary Medicine (2009)

Article Respiratory System

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells

Amy N. Savitski et al.

RESPIRATORY RESEARCH (2009)

Article Biochemistry & Molecular Biology

E-ring isoprostanes stimulate a Cl- conductance in airway epithelium via prostaglandin E-2-selective prostanoid receptors

Victoria Seto et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

8-iso-PGE2 stimulates anion efflux from airway epithelial cells via the EP4 prostanoid receptor

Andrew P. Joy et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Cigarette smoke induces an unfolded protein response in the human lung - A proteomic approach

Steven G. Kelsen et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Distal airways in mice exposed to cigarette smoke - Nrf2-regulated genes are increased in Clara cells

Tracy L. Adair-Kirk et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Oxidative stress caused by pyocyanin impairs CFFR Cl- transport in human bronchial epithelial cells

Christian Schwarzer et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Chemistry, Analytical

In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure

Lucy A. Clunes et al.

JOURNAL OF ANALYTICAL TOXICOLOGY (2008)

Article Biochemistry & Molecular Biology

The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response

Rafal Bartoszewski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Food Science & Technology

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

Jan F. Stevens et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2008)

Review Pharmacology & Pharmacy

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

Frans G. M. Russel et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

Review Chemistry, Medicinal

Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls

Giancarlo Aldini et al.

MEDICINAL RESEARCH REVIEWS (2007)

Article Biochemistry & Molecular Biology

Redox regulation of cAMP-dependent protein kinase signaling - Kinase versus phosphatase inactivation

Kenneth M. Humphries et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells

Margaretha van der Deen et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2007)

Article Biochemistry & Molecular Biology

Oxidant-induced activation of type I protein kinase a is mediated by RI subunit interprotein disulfide bond formation

Jonathan P. Brennan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Pharmacology & Pharmacy

Paradoxical effects of hydrogen peroxide on human airway anion secretion

Takamasa Ohashi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Article Peripheral Vascular Disease

Aquaporin-1 transports NO across cell membranes

Marcela Herrera et al.

HYPERTENSION (2006)

Article Critical Care Medicine

Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers

Andre M. Cantin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Review Cell Biology

Protein carbonylation, cellular dysfunction, and disease progression

Isabella Dalle-Donne et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2006)

Article Respiratory System

The effect of tiotropium on exacerbations and airflow in patients with COPD

D Dusser et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

Article Cell Biology

Oxidant stress suppresses CFTR expression

AM Cantin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)

Review Biochemistry & Molecular Biology

Metals in cigarette smoke

D Bernhard et al.

IUBMB LIFE (2005)

Article Biochemistry & Molecular Biology

Acrolein-induced cell death in PC12 cells: Role of mitochondria-mediated oxidative stress

J Luo et al.

NEUROCHEMISTRY INTERNATIONAL (2005)

Article Physiology

Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract

JL Kreindler et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Physiology

Reversible silencing of CFTR chloride channels by glutathionylation

W Wang et al.

JOURNAL OF GENERAL PHYSIOLOGY (2005)

Article Physiology

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

R Barber et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Reevaluating gel-forming mucins' roles in cystic fibrosis lung disease

J Perez-Vilar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Neurosciences

Transcellular thiocyanate transport by human airway epithelia

MA Fragoso et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

Article Multidisciplinary Sciences

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

G Reid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Pharmacology & Pharmacy

Isoprostane-mediated secretion from human airway epithelial cells

EA Cowley

MOLECULAR PHARMACOLOGY (2003)

Article Pathology

An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke

M Aufderheide et al.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2003)

Article Critical Care Medicine

Hydrogen peroxide-scavenging properties of normal human airway secretions

S El-Chemaly et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

Article Multidisciplinary Sciences

A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

AP Naren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Gastroenterology & Hepatology

Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion

J Walker et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

Article Multidisciplinary Sciences

Acrylamide is formed in the Maillard reaction

DS Mottram et al.

NATURE (2002)

Review Physiology

Antioxidant responses to oxidant-mediated lung diseases

SAA Comhair et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)

Article Critical Care Medicine

Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis

AH Snyder et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

Article Biochemistry & Molecular Biology

S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation

K Zaman et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Physiology

Regulation of the CFTR channel by phosphorylation

D Dahan et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)

Article Biochemistry & Molecular Biology

The lactoperoxidase system functions in bacterial clearance of airways

C Gerson et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)

Review Respiratory System

Oxidative stress and regulation of glutathione in lung inflammation

I Rahman et al.

EUROPEAN RESPIRATORY JOURNAL (2000)