期刊
AMERICAN JOURNAL OF GASTROENTEROLOGY
卷 118, 期 1, 页码 168-173出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.14309/ajg.0000000000001995
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This study assessed the impact of long-term albumin administration on hyponatremic patients with ascites enrolled in the ANSWER trial. The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated. The results showed that albumin treatment had a higher hyponatremia normalization rate compared to standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin administration ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).
INTRODUCTION:We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial.METHODS:The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated.RESULTS:The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167-0.359], P < 0.001).DISCUSSION:Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.
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