Editorial: wireless pH-monitoring - is it time to put away the pH-impredance catheters: Authors' response

Article Gastroenterology & Hepatology

ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease

Philip O. Katz et al.

Summary: This article provides updated recommendations and practical guidance for the evaluation and management of GERD, including pharmacologic, lifestyle, surgical, and endoscopic management. The use of proton pump inhibitors (PPIs) has raised concerns about long-term safety and overprescribing. New data regarding surgical and endoscopic interventions have also emerged.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Clinical role of ambulatory reflux monitoring in PPI non-responders: Recommendation statements

Rena Yadlapati et al.

Summary: Through the use of the RAND Appropriateness Method (RAM) and expert opinions, this study provides recommendations for the use of ambulatory reflux monitoring in clinical practice. It identifies the appropriate diagnostic tool, monitoring protocol, and thresholds for assessing the need for acid suppression in reflux patients. The study also explores different scenarios and criteria for escalating anti-reflux treatment based on the monitoring results.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Optimal Wireless Reflux Monitoring Metrics to Predict Discontinuation of Proton Pump Inhibitor Therapy

Rena Yadlapati et al.

Summary: This clinical trial found that a total acid exposure time (AET) of 4.0% is a high-performing prognostic marker for discontinuing PPI therapy. 96 hours of monitoring performed better than 48 hours in predicting the ability to discontinue PPI. These findings have implications for the diagnostic approaches for patients with GERD symptoms who are unresponsive to PPI therapy.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Ambulatory Reflux Monitoring Guides Proton Pump Inhibitor Discontinuation in Patients With Gastroesophageal Reflux Symptoms: A Clinical Trial

Rena Yadlapati et al.

Summary: This study showed that in patients with typical reflux symptoms, inadequate PPI response, and absence of severe esophagitis, acid exposure on reflux monitoring could predict the ability to discontinue PPIs without symptom escalation. Symptom burden reduction was greater among those who discontinued PPI compared to those who resumed. It is suggested that upfront reflux monitoring off acid suppression can help limit unnecessary PPI use and guide personalized management.

GASTROENTEROLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Value of pH Impedance Monitoring While on Twice-Daily Proton Pump Inhibitor Therapy to Identify Need for Escalation of Reflux Management

C. Prakash Gyawali et al.

Summary: Abnormal metrics identified in pH impedance studies performed while on PPI therapy are associated with nonresponse in patients with proven GERD, providing guidance for treatment escalation, including surgical intervention, especially in regurgitation-predominant GERD cases.

GASTROENTEROLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology