期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 38, 期 10, 页码 779-781出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2022.0058
关键词
HIV; doravirine; real life; efficacy; safety
Doravirine (DOR) has shown good efficacy and safety in adult naive or treated patients, making it a safe and relevant strategy to avoid drug interactions and drugs with poor metabolic tolerance.
Doravirine (DOR) efficacy and safety have been evaluated in adult naive or treated patients starting a DOR-based regimen between September 15, 2019, and December 31, 2020. Medical history and examination, laboratory results, and tolerance were assessed during the 48 weeks of follow-up. Among the 77 patients included, virological control (VC) was noticed for 66 patients at baseline. Median age was 51 years, and 62% were men. The most common reason for initiating a DOR-based therapy was toxicity (44; 67%) and, especially, weight gain. A virological suppression (VS) was maintained in 55 (83%) patients of the VC group and noticed in 9 (82%) of the non-VC patients at week 48, by intention-to-treat analysis. On treatment analysis, 98% and 100% patients achieved VS in the VC and non-VC groups, respectively. The renal and metabolic tolerance were good. DOR-based regimens appear to be a safe and relevant strategy to circumvent drug interactions and drugs with a poor metabolic tolerance profile.
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