期刊
ADVANCES IN COLLOID AND INTERFACE SCIENCE
卷 309, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.cis.2022.102791
关键词
Calcium carbonate; Advanced delivery system; Controlled release; Encapsulation; Bioactives
资金
- National Natural Science Foundation of China for Young Scholars [32101879]
- Beijing Municipal Natural Science Committee Beijing Municipal Education Committee Joint Fund [KZ201810011014]
- High-level Teachers in Beijing Municipal Universities [IDHT20180506]
- Beijing Excellent Talents Funding for Youth Scientist Innovation Team [2016000026833TD01]
- Chinese Ministry of Science and Technology the Belt and Road Innovative Talent Exchange Foreign Expert Project [DL2021003001]
This review article discusses the recent progress in utilizing calcium carbonate particles in various advanced delivery systems. The challenges in rapid dissolution, low retention ability, and lack of sustained release are addressed through modification and integration with other encapsulation systems. The applications and challenges of these advanced systems for the protection and controlled delivery of bioactive compounds in the biological, pharmaceutical, and functional food fields are emphasized.
Calcium carbonate (CaCO3) has long been used as a delivery system owing to its wide availability, biocom-patibility, and degradability. However, it often suffers from many challenges toward rapid dissolution at stomach acid environment, low retention ability, and lack of sustained release. Many of these issues can be addressed by modifying the CaCO3 particles or integrating them with other encapsulation systems, generating advanced CaCO3-derived systems. This review article presents a recent progress (2015-2022) in the utilization of CaCO3 particles in the exploration of various advanced delivery systems, including polymer-doped CaCO3, surface-coated CaCO3, CaCO3-stabilized Pickering emulsions, CaCO3-in-hydrogels, and liposomal CaCO3. Some emerging systems templated on CaCO3 sacrificial cores, such as hollow capsules, matrix-type capsules, and core-shell capsules, are also reviewed. A brief description of each system is given, and then their formation, structure, and properties are described. Particular emphasis is given to the applications and challenges of these advanced systems for the protection and controlled delivery of bioactive compounds in the biological, pharmaceutical, and functional food fields.
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