Carbene Catalyzed Asymmetric Synthesis of Selenylated delta-Lactones via [4+2] Annulation of Selenyl Vinyl Ketones and Enals

A direct (organo)catalytic method for the synthesis of chiral selenylated delta-lactones via [4+2] annulation of selenyl vinyl ketones with enals has been achieved. The C5-selenylated dihydropyranones were obtained in 54-88% yield with 90-99% enantioselectivity.

Automated summary

A direct catalytic method for the synthesis of chiral selenylated delta-lactones via [4+2] annulation has been achieved. The C5-selenylated dihydropyranones were obtained in high yield and with high enantioselectivity.