Construction of Cyclopenta[b]naphthalenol Frameworks by Weinreb Amide-Directed Umpolung Ring Opening of Methylenecyclopropanes

A cascade cyclization from Weinreb amide-tethered methylenecyclopropanes and alkynes has been disclosed in this paper, which extends the umpolung ring opening of methylenecyclopropanes, giving a synthetic approach for the construction of polycyclic cyclopenta[b]naphthalenol framework. In the protocol, four carbon-carbon bonds and two carbocycles are formed without the use of transition metals, providing a tool for constructing the structure-related polycyclic compounds.

Automated summary

A cascade cyclization method using Weinreb amide-tethered methylenecyclopropanes and alkynes is disclosed in this paper, which extends the umpolung ring opening of methylenecyclopropanes and provides a synthetic approach for constructing polycyclic cyclopenta[b]naphthalenol framework.