期刊
ADVANCED MATERIALS
卷 34, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202205924
关键词
covalent organic frameworks; imine exchange reaction; sonodynamic therapy; immunotherapy
类别
资金
- National Key Research and Development Program of China [2021YFB3800900]
- National Natural Science Foundation of China [51925305, 51873208, 51833010, 51803210, 51973217]
- Jilin province science and technology development program [20200201075JC]
A covalent organic framework (COF) sonosensitizer is developed using a new nanoscale COF preparation strategy, which improves the therapeutic effect of sonodynamic therapy (SDT). The COF structure prevents aggregation of the sonosensitizer molecules and enhances their chemical stability. Additionally, the coordination of Fe3+ to COF enables chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and alpha-PD-L1 antibody achieves effective antitumor effects.
To improve the therapeutic effect of sonodynamic therapy (SDT), more effective and stable sonosensitizers and therapeutic strategies are still required. A covalent organic framework (COF) sonosensitizer is developed by using a new nanoscale COF preparation strategy. This strategy uses molecular etching based on the imine exchange reaction to etch the bulk COF into nanoparticles and has universal applicability to imine-bond-based COF. The regular COF structure can prevent the loss of sonodynamic performance caused by the aggregation of porphyrin molecules and improve the chemical stability of the porphyrin unit. In addition, the coordination of Fe3+ to COF endows the nanoparticle with chemodynamic therapy performance and glutathione consumption ability. The combination of enhanced SDT and alpha-PD-L1 antibody achieves a good antitumor effect. The innovative nanoscale COF sonosensitizer preparation strategy provides a new avenue for clinical antitumor therapy.
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