Crossing borders in Alzheimer?s disease: A T cell?s perspective

Article Clinical Neurology

The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model

Christel Claes et al.

Summary: The PLCG2-P522R variant increases the capacity of microglia to recruit T cells and present antigens, promoting the pathological changes associated with Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2022)

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Article Biochemistry & Molecular Biology

Peripheral immunity is associated with the risk of incident dementia

Ya-Ru Zhang et al.

Summary: This study examined the association between peripheral immunity markers and incident dementia using data from the UK Biobank. The results showed that increased innate immunity markers were associated with higher dementia risk, while increased adaptive immunity markers were associated with lower dementia risk. These findings provide new insights into the etiology and therapy of dementia.

MOLECULAR PSYCHIATRY (2022)

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Article Multidisciplinary Sciences

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

Andrew C. Yang et al.

Summary: This study provides a molecular map of vascular and perivascular cell types in the human brain using a method called VINE-seq, revealing their contributions to Alzheimer's disease risk.

NATURE (2022)

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Article Multidisciplinary Sciences

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

Tobias Lanz et al.

Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Choroid Plexus in Alzheimer's Disease-The Current State of Knowledge

Tiago Giao et al.

Summary: The choroid plexus is a monolayer of epithelial cells in the brain ventricles that forms a blood-cerebrospinal fluid barrier. It secretes cerebrospinal fluid and plays a role in immune surveillance and toxin removal. Impaired function of the choroid plexus is associated with diseases like Alzheimer's, and therapies to restore its function are being proposed.

BIOMEDICINES (2022)

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Article Neurosciences

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

Jose A. Mazzitelli et al.

Summary: The study reveals that cerebrospinal fluid gains direct access to skull bone marrow niches via dura-skull channels and the proteins in the cerebrospinal fluid can signal onto diverse cell types within these niches. After spinal cord injury, the cues from cerebrospinal fluid promote myelopoiesis and the release of myeloid cells into the meninges.

NATURE NEUROSCIENCE (2022)

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Article Neurosciences

Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

Xiaojing Li et al.

Summary: This study reveals the role of meningeal lymphatic vessels (MLVs) in transporting viruses from the CNS to cervical lymph nodes during acute viral infection. Functional expansion of MLVs promotes virus clearance and reduces neurological damage.

NATURE NEUROSCIENCE (2022)

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Article Neurosciences

Decreased CSF clearance and increased brain amyloid in Alzheimer's disease

Yi Li et al.

Summary: This study found reduced CSF clearance in Alzheimer's disease, which is associated with brain amyloid-beta deposition and cognitive decline.

FLUIDS AND BARRIERS OF THE CNS (2022)

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Article Immunology

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan et al.

Summary: Studies have shown that PD-1-deficient T reg cells exhibit enhanced immunosuppressive function through reduced signaling through the PI3K-AKT pathway. This finding demonstrates that cell-intrinsic PD-1 restraint of T reg cells is a significant mechanism by which PD-1 inhibitory signals regulate T cell tolerance and autoimmunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

The Gene Ontology resource: enriching a GOld mine

Seth Carbon et al.

Summary: The Gene Ontology Consortium has made advancements in the last two years, such as improving the GO-CAM annotation framework, increasing the number of annotations and annotated gene products, and reviewing older annotations for consistency.

NUCLEIC ACIDS RESEARCH (2021)

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Article Immunology

CD4+effector T cells accelerate Alzheimer's disease in mice

Jatin Machhi et al.

Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Article Endocrinology & Metabolism

Immune function, cortisol, and cognitive decline & dementia in an aging latino population

Rebecca C. Stebbins et al.

Summary: This study investigated the role of the peripheral immune system in cognitive decline, finding that IL-6, TNF-alpha, and CMV IgG were significantly associated with cognitive decline. However, no significant relationship was found between these biomarkers and incident dementia.

PSYCHONEUROENDOCRINOLOGY (2021)

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Review Neurosciences

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

Gianfranco Natale et al.

Summary: Recent studies on nervous lymphatic drainage and the blood-brain barrier have revealed a glymphatic pathway in the brain, similar to the peripheral lymphatic system. This pathway allows for the clearance of waste products from the brain, challenging the classic concept of the brain's immune privilege. Research is also exploring the potential role of the glymphatic pathway in neurodegenerative diseases and other acute neurological disorders.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Clinical Neurology

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease

Daniel Asby et al.

Summary: Our study found that multiple brain cytokines were elevated in Alzheimer's disease and vascular dementia, and systemic infection exacerbated cerebral hypoperfusion and blood-brain barrier leakiness associated with these dementias. The level of insoluble amyloid-beta did not seem to play a significant role in these effects.

BRAIN (2021)

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Article Neurosciences

Extensive frontal focused ultrasound mediated blood-brain barrier opening for the treatment of Alzheimer's disease: a proof-of-concept study

So Hee Park et al.

Summary: The study aimed to evaluate the safety and potential benefits of repeated extensive BBB opening for patients with AD. Results indicated that the therapy could help remove amyloid plaque to some extent, but further research is needed to ensure the sustainability of the effects.

TRANSLATIONAL NEURODEGENERATION (2021)

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Article Neurosciences

Low-grade peripheral inflammation affects brain pathology in the AppNL-G-Fmouse model of Alzheimer's disease

Junhua Xie et al.

Summary: Alzheimer's disease is characterized by accumulation of amyloid beta and neurofibrillary tangles, with neuroinflammation playing a key role in its progression. Low-grade peripheral inflammation affects microglia characteristics, blood-cerebrospinal fluid barrier integrity, immune cell infiltration, and A beta deposition in the brain in the APP knock-in mouse model, potentially through mechanisms like A beta efflux and neuronal dysfunction. These findings suggest modulating peripheral inflammation could be a therapeutic strategy for AD.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

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News Item Geriatrics & Gerontology

Neuronal ApoE and MHC-I expression in Alzheimer's disease

Jack Williamson

LANCET HEALTHY LONGEVITY (2021)

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Article Multidisciplinary Sciences

Herpes simplex virus 1 and the risk of dementia: a population-based study

Meghan J. Murphy et al.

Summary: HSV1 is associated with cognitive decline but not with incident dementia in the general population. These data suggest HSV1 to be associated only with subtle cognitive disturbances but not with greater cognitive disorders that result in dementia. The findings highlight the need for further research to fully understand the relationship between HSV1 and dementia risk.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and cis-Spliced Zwitter Epitope Candidates in Type 1 Diabetes

Michele Mishto et al.

Summary: Increasing evidence indicates that post-translational peptide splicing can affect immune responses, especially in Type 1 Diabetes. Spliced peptides have variable sequences, increasing the risk of viral-human zwitter peptides. Some viral-human zwitter peptides may be produced by proteasome-catalyzed peptide splicing, enhancing the destruction of pancreatic beta cells by virus-specific CD8(+) T cells.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Microglia in Alzheimer's disease at single-cell level. Are there common in humans and mice?

Yun Chen et al.

Summary: Alzheimer's disease is characterized by the activation of microglia in response to amyloid beta peptides and tau aggregates, leading to the conversion of homeostatic microglia into disease-associated microglia. Different populations of reactive microglia have been identified, suggesting that microglia play a critical role in disease progression. Further research into the impact of microglia in AD pathogenesis is needed to better understand the parallels and discrepancies between human and mouse models.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Genetics & Heredity

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease

Douglas P. Wightman et al.

Summary: This study identified seven new genetic loci associated with Alzheimer's disease through a genome-wide association study, implicating microglia and immune cells in late-onset disease. The research highlights the relevance of microglia, immune cells, and protein catabolism to late-onset Alzheimer's disease, while prioritizing previously unidentified genes for further investigation. The results are expected to contribute to larger meta-analyses to uncover additional genetic variants affecting Alzheimer's pathology.

NATURE GENETICS (2021)

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Review Immunology

Immune cell compartmentalization for brain surveillance and protection

Tommaso Croese et al.

Summary: The brain is not completely isolated from external immune activity, with microglia and a lymphatic drainage system present within it. The discovery and study of peripheral immune cells have proposed a new understanding of the immune function in the brain.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Andrea Cugurra et al.

Summary: The meninges contain a pool of monocytes and neutrophils supplied by adjacent skull and vertebral bone marrow, rather than by the blood. Under pathological conditions, CNS-infiltrating myeloid cells can originate from the brain borders and have distinct transcriptional signatures from their blood-derived counterparts. Therefore, myeloid cells from adjacent bone marrow niches are strategically placed to supply innate immune cells under both homeostatic and pathological conditions.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

Simone Brioschi et al.

Summary: The meninges contain adaptive immune cells called B cells that are thought to originate locally from the calvaria, providing a constant supply of CNS-educated B cells. Additionally, a subset of antigen-experienced B cells in the meninges of aging mice are found to be blood-borne, suggesting a potential mechanism for maintaining immune privilege within the CNS.

SCIENCE (2021)

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Review Neurosciences

Dysregulation of Systemic Immunity in Aging and Dementia

Jenny Lutshumba et al.

Summary: Neuroinflammation involves interactions between microglia, systemic immune cells, and cytokines, with changes orchestrated by immune cells in both the brain and peripheral system. Both innate and adaptive immune cells, such as T cells and B cells, contribute to chronic neuroinflammation and dementia. Neurodegenerative pathology, infection, or injury can combine to trigger persistent microglial and brain inflammation, with lymphocytes playing a key role in inflammation and potential dementia progression.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Cell Biology

IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease

Helena C. Brigas et al.

Summary: The study found that in Alzheimer's disease models, there is an accumulation of interleukin 17-producing cells in the brain and meninges of female mice, which is associated with cognitive decline. Additionally, neutralization of interleukin 17 can prevent early memory and synaptic plasticity deficits, suggesting an early involvement of interleukin 17 in Alzheimer's disease pathology.

CELL REPORTS (2021)

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Review Neurosciences

Blood-Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia

Basharat Hussain et al.

Summary: The review discusses the crucial role of the blood-brain barrier in maintaining the specialized microenvironment of neural tissue and the associated BBB breakdown with normal aging and various neurodegenerative diseases. It also covers dementia such as AD and VaD, and the phenotypes and mechanisms of BBB disruption correlated with cognitive decline. The study suggests that BBB breakdown could serve as an emerging biomarker to assist in diagnosing cognitive impairment associated with normal aging and dementia.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Immunology

A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+T-Regulatory Cells

Eros Di Giorgio et al.

Summary: The Mads/Mef2 family of transcription factors regulate differentiation in various cell types and are involved in physiological feedback loops. Disruption of their interaction with Hdac9 can lead to the development of pathologic states, including cancer. These transcription factors also indirectly control tumor progression by regulating antitumor immunity, particularly in Treg cells, adding complexity to the study of Treg biology.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β

Axel Montagne et al.

Summary: This study demonstrates that APOE4 accelerates advanced-stage vascular dysfunction and neurodegeneration in old mice independently of amyloid-beta by activating the cyclophilin A pathway in pericytes. This has implications for the pathogenesis and treatment of vascular and neurodegenerative disorders in Alzheimer's disease.

NATURE AGING (2021)

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Article Neurosciences

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease

Kelly A. Zalocusky et al.

Summary: Selective neurodegeneration is a critical causal factor in Alzheimer's disease, and a study has demonstrated a causal relationship between neuronal ApoE expression and MHC-I expression leading to tau pathology and selective neurodegeneration. The correlation between ApoE expression and immune response pathways suggests a mechanism for the vulnerability of certain neurons in Alzheimer's disease.

NATURE NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

Sandro Da Mesquita et al.

Summary: This study investigated the impact of aging on brain function, revealing an immune cell pathway associated with brain aging and cognitive decline. The research found that a reduction in CCR7 expression in old mice affected the transfer of immune cells through the lymphatic vasculature, leading to cognitive impairment and brain Aβ deposition.

SCIENCE ADVANCES (2021)

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Letter Oncology

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Erik B. van den Akker et al.

LEUKEMIA (2021)

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Article Multidisciplinary Sciences

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease

David Gate et al.

NATURE (2020)

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Article Neurosciences

Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts

Mary Alice Allnutt et al.

NEURON (2020)

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Article Multidisciplinary Sciences

A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis

Siva Sai Krishna Venigalla et al.

SCIENTIFIC REPORTS (2020)

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Article Cell Biology

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology

Alma Nazlie Mohebiany et al.

CELL REPORTS (2020)

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Article Immunology

CD8+ T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

M. S. Unger et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Clinical Neurology

Exploratory study on immune phenotypes in Alzheimer's disease and vascular dementia

C. D'Angelo et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Multidisciplinary Sciences

Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound

Ali R. Rezai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Clinical Neurology

Long-term safety and effectiveness of natalizumab treatment in clinical practice: 10 years of real-world data from the Tysabri Observational Program (TOP)

Helmut Butzkueven et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

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Article Multidisciplinary Sciences

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

Axel Montagne et al.

NATURE (2020)

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Article Neurosciences

Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer's Disease

Hector Rosas-Hernandez et al.

NEUROSCIENCE (2020)

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Review Neurosciences

Choroid plexus and the blood-cerebrospinal fluid barrier in disease

Peter Solar et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

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Review Cell Biology

Proteomics as a reliable approach for discovery of blood-based Alzheimer's disease biomarkers: A systematic review and meta-analysis

Siti Hajar Rehiman et al.

AGEING RESEARCH REVIEWS (2020)

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Review Clinical Neurology

Update on T cells in the virally infected brain: friends and foes

Shenjian Ai et al.

CURRENT OPINION IN NEUROLOGY (2020)

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Article Geriatrics & Gerontology

Prospective longitudinal evaluation of cytokines in mild cognitive impairment due toADand Lewy body disease

Alan J. Thomas et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2020)

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Review Cell Biology

Neutrophil activation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of protein markers in blood and cerebrospinal fluid

Che-Yuan Wu et al.

AGEING RESEARCH REVIEWS (2020)

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Review Multidisciplinary Sciences

Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases

Tim Bartels et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease

Marta Olah et al.

NATURE COMMUNICATIONS (2020)

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Article Clinical Neurology

Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion

Alireza Faridar et al.

BRAIN COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Xiaoliang Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

TIM3 comes of age as an inhibitory receptor

Yochai Wolf et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Clinical Neurology

Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice

Linmei Wang et al.

BRAIN PATHOLOGY (2019)

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Article Clinical Neurology

Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression

Yu Yamazaki et al.

BRAIN (2019)

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Article Genetics & Heredity

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle et al.

NATURE GENETICS (2019)

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Article Multidisciplinary Sciences

Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

Emmanuelle Coque et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Geriatrics & Gerontology

Peripheral inflammatory biomarkers in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis

Cen Su et al.

PSYCHOGERIATRICS (2019)

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Article Geriatrics & Gerontology

Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time

Brianne M. Bettcher et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

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Article Immunology

Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study

Kimberly D. van der Willik et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Review Immunology

The pathogenicity of Th17 cells in autoimmune diseases

Keiko Yasuda et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

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Article Neurosciences

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

Charise Garber et al.

NATURE NEUROSCIENCE (2019)

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Review Clinical Neurology

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yu Yamazaki et al.

NATURE REVIEWS NEUROLOGY (2019)

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Article Multidisciplinary Sciences

Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies

Petra Majerova et al.

PLOS ONE (2019)

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Article Multidisciplinary Sciences

The Characterization of Regulatory T-Cell Profiles in Alzheimer's Disease and Multiple Sclerosis

Fausta Ciccocioppo et al.

SCIENTIFIC REPORTS (2019)

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Review Immunology

The anatomy and immunology of vasculature in the central nervous system

Panagiotis Mastorakos et al.

SCIENCE IMMUNOLOGY (2019)

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Article Geriatrics & Gerontology

Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD

Alden L. Gross et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

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Review Biochemistry & Molecular Biology

Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers

Mariana Castro Dias et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Neurosciences

Enlarged Perivascular Spaces and Dementia: A Systematic Review

David Smeijer et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Multidisciplinary Sciences

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Kosuke Hashimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Anatomy & Morphology

Th17 and Cognitive Impairment: Possible Mechanisms of Action

Virginia Cipollini et al.

FRONTIERS IN NEUROANATOMY (2019)

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Article Cell Biology

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

Enzo Tedone et al.

AGING CELL (2019)

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Article Multidisciplinary Sciences

Blockade of α4 integrins reduces leukocyte-endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease

Enrica Pietronigro et al.

SCIENTIFIC REPORTS (2019)

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Article Cell Biology

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Maria Daglas et al.

CELL REPORTS (2019)

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Article Neurosciences

KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections

Roberta Rizzo et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Biotechnology & Applied Microbiology

Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress

Maria Anele Romeo et al.

JOURNAL OF GENERAL VIROLOGY (2019)

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Review Clinical Neurology

Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies

Xue-Ning Shen et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

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Article Genetics & Heredity

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk

Iris E. Jansen et al.

NATURE GENETICS (2019)

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Article Biochemistry & Molecular Biology

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction

Daniel A. Nation et al.

NATURE MEDICINE (2019)

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Review Immunology

Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance

Ruihan Tang et al.

SEMINARS IN IMMUNOLOGY (2019)

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Review Cell Biology

Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease?

Maria Anele Romeo et al.

NEURAL REGENERATION RESEARCH (2019)

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Article Clinical Neurology

A genetic signature including apolipoprotein E epsilon 4 potentiates the risk of herpes simplex-associated Alzheimer's disease

Karin Lopatko Lindman et al.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2019)

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Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

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Article Clinical Neurology

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Nazira J. Albargothy et al.

ACTA NEUROPATHOLOGICA (2018)

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Article Clinical Neurology

Neutrophil hyperactivation correlates with Alzheimer's disease progression

Yuan Dong et al.

ANNALS OF NEUROLOGY (2018)

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Article Neurosciences

Reaction of Amyloid-β Peptide Antibody with Different Infectious Agents Involved in Alzheimer's Disease

Aristo Vojdani et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Clinical Neurology

The effect of &ITAPOE&IT and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Sven J. van der Lee et al.

LANCET NEUROLOGY (2018)

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Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

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Article Clinical Neurology

Extravascular CD3+T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

Mario Merlini et al.

NEURODEGENERATIVE DISEASES (2018)

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Article Neurosciences

Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

Ben Readhead et al.

NEURON (2018)

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Article Neurosciences

Characterization of Impaired Cerebrovascular Structure in APP/PS1 Mouse Brains

Kee-Chan Ahn et al.

NEUROSCIENCE (2018)

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Editorial Material Neurosciences

Microbes and Alzheimer's Disease: New Findings Call for a Paradigm Change

Juergen G. Haas et al.

TRENDS IN NEUROSCIENCES (2018)

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Article Multidisciplinary Sciences

Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound

Nir Lipsman et al.

NATURE COMMUNICATIONS (2018)

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Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation

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Mechanisms of Disease: Interleukin-17 and Type 17 Helper T Cells.

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Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis

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Systemic immune aberrations in Alzheimer's disease patients

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Higher frequency of regulatory T suppressive activity cells in the elderly and increased in neurodegeneration

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Telomere shortening in T cells correlates with Alzheimer's disease status

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Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

T Togo et al.

JOURNAL OF NEUROIMMUNOLOGY (2002)

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Article Clinical Neurology

Morphological alterations of the choroid plexus in late-onset Alzheimer's disease

JM Serot et al.

ACTA NEUROPATHOLOGICA (2000)

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Crossing borders in Alzheimer?s disease: A T cell?s perspective

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