4.7 Review

Harnessing immune response using reactive oxygen Species-Generating/Eliminating inorganic biomaterials for disease treatment

期刊

ADVANCED DRUG DELIVERY REVIEWS
卷 188, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.addr.2022.114456

关键词

Reactive oxygen species (ROS); Inorganic biomaterials; Immunomodulation; Immune response; Biomedical application

资金

  1. National Natural Science Foundation of China [32171320, 82102213]
  2. Xi'an association for Science and Technology Young Talent Support Project [91803210003, 095920221341]
  3. Qinchuangyuan cited the high-level innovation and entrepreneurship talent program [QCYRCXM-2022-27]
  4. State Key Laboratory of Veterinary Biotechnology Foundation [SKLVBF202207]
  5. Fundamental Research Funds for the Central Universities [QTZX22067]
  6. Opening Project of the State Key Laboratory of Microbial Resources [SKLMR-20220703]
  7. Innovation Capability Support Program of Shaanxi [2022TD-52]
  8. Natural Science Foundation of Shaanxi Pro- vince of China [2020PT-020]
  9. National University of Singapore Startup Fund [NUHSRO/2020/133/Startup/08]
  10. NUS School of Medicine Nanomedicine Translational Research Program [NUHSRO/2021/034/TRP/09/Nanomedicine]
  11. National Medical Research Council (NMRC) Centre Grant Programme [CG21APR1005]

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This review provides an overview of the latest progress in ROS-nanotechnology mediated immunomodulation. Inorganic biomaterials can modulate immune responses by generating or eliminating ROS, with potential applications in combating inflammation, autoimmune diseases, and cancers.
With the increasing understanding of various biological functions mediated by reactive oxygen species (ROS) in the immune system, a number of studies have been designed to develop ROS-generating/ eliminating strategies to selectively modulate immunogenicity for disease treatment. These strategies potentially exploit ROS-modulating inorganic biomaterials to harness host immunity to maximize the therapeutic potency by eliciting a favorable immune response. Inorganic biomaterial-guided in vivo ROS scavenging can exhibit several effects to: i) reduce the secretion of pro-inflammatory factors, ii) induce the phenotypic transition of macrophages from inflammatory M1 to immunosuppressive M2 phase, iii) minimize the recruitment and infiltration of immune cells. and/or iv) suppress the activation of nuclear factor kappa-B (NF -KB) pathway. Inversely, ROS-generating inorganic biomaterials have been found to be capable of: i) inducing immunogenic cell death (ICD), ii) reprograming tumor-associated macrophages from M2 to M1 phenotypes, iii) activating inflammasomes to stimulate tumor immunogenicity, and/or iv) recruiting phagocytes for antimicrobial therapy. This review provides a systematic and up-to-date overview on the progress related to ROS-nanotechnology mediated immunomodulation. We highlight how the ROS-generating/eliminating inorganic biomaterials can converge with immunomodulation and ultimately elicit an effective immune response against inflammation, autoimmune diseases, and/or cancers. We expect that contents presented in this review will be beneficial for the future advancements of ROS-based nanotechnology and its potential applications in this evolving field. (C) 2022 Elsevier B.V. All rights reserved.

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