期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 189, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2022.114483
关键词
Phototheranostics; Near-infrared; Multifunctional Nanoparticles; Fluorescence; Cancer therapy; Photodynamic therapy; Photothermal therapy; Photoimmunotherapy; Image-guided gene therapy
资金
- NIBIB [R01EB022230]
- NHLBI [R01HL143020]
- National Research Foundation of Korea [2019M3D1A1078938]
- National Natural Science Foundation of China (NSFC) [81802453]
- Key Research and Development Program of Shaanxi Province [2019SF-093]
- Basic Scientific Research Interdisciplinary and Cooperation Project of Xian Jiaotong University [1119293853]
- ZTI Biosciences [2020A015360]
Phototheranostics combine light-induced therapeutic and diagnostic modalities to diagnose and treat human diseases. The development of nanomedicines and bioimaging has led to the advancement of phototheranostics, which show potential in improving treatment efficacy and minimizing side effects.
Phototheranostics stem from the recent advances in nanomedicines and bioimaging to diagnose and treat human diseases. Since tumors' diversity, heterogeneity, and instability limit the clinical application of traditional diagnostics and therapeutics, phototheranostics, which combine light-induced therapeutic and diagnostic modalities in a single platform, have been widely investigated. Numerous efforts have been made to develop phototheranostics for efficient light-induced antitumor therapeutics with minimal side effects. Herein, we review the fundamentals of phototheranostic nanomedicines with their biomed-ical applications. Furthermore, the progress of near-infrared fluorescence imaging and cancer treatments, including photodynamic therapy and photothermal therapy, along with chemotherapy, immunotherapy, and gene therapy, are summarized. This review also discusses the opportunities and challenges associ-ated with the clinical translation of phototheranostics in pan-cancer research. Phototheranostics can pave the way for future research, improve the quality of life, and prolong cancer patients' survival times.CO 2022 Elsevier B.V. All rights reserved.
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