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Engineering nanosystems to overcome barriers to cancer diagnosis and treatment

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Article Biochemical Research Methods

Surface Modification of Nanoparticles Enhances Drug Delivery to the Brain and Improves Survival in a Glioblastoma Multiforme Murine Model

Kanawat Wiwatchaitawee et al.

Summary: In this study, loading paclitaxel (PTX) into a polymeric, nanoparticulate delivery system improved its accumulation and therapeutic activity in the brain. By incorporating positively charged surface modifiers onto polymeric nanoparticles, significant improvement in brain accumulation was achieved. The efficacy of PTX-loaded nanoparticles with a specific surface modifier was demonstrated in a mouse model of GBM, showing improved survival and equivalent safety compared to soluble PTX.

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Article Oncology

Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study

Arlene O. Siefker-Radtke et al.

Summary: This study evaluated the long-term efficacy and safety of Erdafitinib in patients with locally advanced or metastatic urothelial carcinoma. The results showed consistent activity and manageable safety profile in these patients.

LANCET ONCOLOGY (2022)

Review Medicine, Research & Experimental

Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

Luman Liu et al.

Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.

THERANOSTICS (2022)

Review Chemistry, Multidisciplinary

Stimuli-Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Jin Zhang et al.

Summary: This review discusses the use of stimuli-responsive nanoparticles (srNPs) in cancer immunotherapy, highlighting their potential to enhance anti-tumor immune responses by combining with tumor microenvironment and external stimuli. The goal is to achieve synergistic immunotherapy and long-term immune memory to prevent tumor recurrence.

ADVANCED SCIENCE (2022)

Article Multidisciplinary Sciences

Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine

Rasheid Smith et al.

Summary: Nanoscale formulations can enhance the efficacy of cancer vaccines by combating the immunosuppressive nature of the tumor microenvironment. A newly synthesized nanoparticulate formulation demonstrated adjuvant properties in vivo, leading to increased TAA-specific T cells, reduced tumor burden, protection against tumor rechallenge, and improved median survival in tumor-challenged mice.

SCIENCE ADVANCES (2022)

Review Oncology

Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance

Melanie A. Krook et al.

Summary: FGFRs are aberrantly activated in 5-10% of human cancers through genetic alterations, with FGFR-targeted therapies showing significant advancements in the past decade. However, acquired drug resistance leading to cancer progression remains a challenge in most patients.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Pharmacology & Pharmacy

Antibody-mediated drug delivery

Fatma Betul Arslan et al.

Summary: Passive and active targeted nanoparticulate delivery systems have the potential to compensate for the shortcomings of conventional therapy. Active targeted delivery systems have not yet been clinically used, but efforts are ongoing to formulate them successfully. Monoclonal antibodies and their fragments as targeting ligands are the main focus of this review.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Biochemistry & Molecular Biology

Design of Biopolymer-Based Interstitial Therapies for the Treatment of Glioblastoma

Erik S. Pena et al.

Summary: Glioblastoma multiforme (GBM) is the most common form of primary brain cancer with poor prognosis, and interstitial therapy offers a promising approach for improving survival rates. By utilizing polymer implants to release drugs locally at the site of resection, interstitial therapy can bypass the blood-brain barrier, reduce systemic toxicity, and optimize combination therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Multidisciplinary

Design of PEGylated Three Ligands Silica Nanoparticles for Multi-Receptor Targeting

Manon Maurel et al.

Summary: This paper demonstrates the achievement of a higher level of controlled multifunctionality by using sol-gel chemistry to conjugate PEG chains and three different ligands on the core of SiNPs, while also addressing the issue of surface ungrafting. The study compares the efficiency of different linking methods and evaluates the tumor-cell-targeting efficiency of multi-ligand SiNPs in human endothelial cells and mixed spheroids in vitro.

NANOMATERIALS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Editorial Material Biotechnology & Applied Microbiology

Toward enzyme-responsive polymersome drug delivery

Bipin Chakravarthy Paruchuri et al.

Summary: Enzyme-responsive drug carriers are increasingly important in drug delivery due to disease pathology associated with enzyme overexpression. Polymersomes are promising for such applications, but pose challenges in developing generalized rules for synthesizing novel systems. This perspective summarizes existing knowledge on enzyme-responsive polymersomes, proposes design heuristics for novel systems, and discusses the potential of an integrated approach using computer simulations and experimental studies to streamline the design process.

NANOMEDICINE (2021)

Article Chemistry, Multidisciplinary

pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects

Lindomar J. C. Albuquerque et al.

Summary: This study demonstrates the use of pH-responsive polymersomes for successful loading and release of doxorubicin in tumor microenvironments, leading to enhanced therapeutic efficacy and increased survival rate in mice.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Biochemistry & Molecular Biology

The role of mRNA in the development, diagnosis, treatment and prognosis of neural tumors

Yiyang Zheng et al.

Summary: Neural tumors, divided into central nervous system tumors and peripheral nervous tumors, are difficult to completely remove by surgery. The majority of neural tumors are malignant and challenging to cure completely even with chemotherapy and radiotherapy. mRNA therapy, as an emerging gene therapy, shows promising research prospects for the treatment of neural tumors.

MOLECULAR CANCER (2021)

Review Oncology

The Role of VEGF Receptors as Molecular Target in Nuclear Medicine for Cancer Diagnosis and Combination Therapy

Katarzyna Maslowska et al.

Summary: The rapid development of diagnostic and therapeutic methods in cancer treatment has led to more effective treatment options. Nuclear medicine plays a significant role in early cancer diagnosis and targeted therapy, which causes less side effects compared to chemotherapy. Targeted anti-angiogenic therapy aims to prevent blood vessel formation around cancer cells, with molecules targeting VEGF/VEGFR showing promise in combination therapeutic strategies. Diagnostic radioagents are crucial in monitoring treatment progress and predicting outcomes in anti-angiogenic therapy.

CANCERS (2021)

Review Polymer Science

Advances in development of the dendrimers having natural saccharides in their structure for efficient and controlled drug delivery applications

Malihe Pooresmaeil et al.

Summary: Dendrimers have been identified as a promising platform for drug delivery, but face limitations. By incorporating saccharides into dendrimers, it is possible to enhance biocompatibility and address certain issues that arise.

EUROPEAN POLYMER JOURNAL (2021)

Review Chemistry, Multidisciplinary

Polymeric micelles in cancer therapy: State of the art

Balaram Ghosh et al.

Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Medicine, Research & Experimental

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Alessandra Spada et al.

Summary: Albumin is an attractive carrier in nanomedicine due to its high biocompatibility, ability to interact with various drugs, and active targeting potential. It has a long serum half-life of around 19 days, promoting half-life extension and targeted drug delivery. The article emphasizes the importance of albumin as a drug delivery system and highlights its potential future trends in drug delivery.

MOLECULAR PHARMACEUTICS (2021)

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Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics

Cole J. Batty et al.

Summary: Nano and micro-technologies are utilized for therapeutic delivery of biologics and small molecules in formulations of varying sizes. These technologies have unique physiochemical properties that result in improved drug pharmacokinetics and reduced toxicity compared to conventional formulations.

TRENDS IN MOLECULAR MEDICINE (2021)

Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

Review Endocrinology & Metabolism

Role of Somatostatin Receptor in Pancreatic Neuroendocrine Tumor Development, Diagnosis, and Therapy

Yuheng Hu et al.

Summary: SSTRs have significant clinical significance in pNETs, serving as important targets for diagnosis and treatment, but further research is needed.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Cell Biology

Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer

Laura Pacini et al.

Summary: Lung cancer is the most common cause of cancer-related deaths globally, and genetic alterations in the FGFR family in non-small cell lung cancer play a role in cancer initiation and progression. Therapies targeting FGFR have been developed, but clinical trials have shown low efficacy in lung cancer patients with FGFR aberrations.
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Piceatannol-Loaded Bilosome-Stabilized Zein Protein Exhibits Enhanced Cytostatic and Apoptotic Activities in Lung Cancer Cells

Nabil A. Alhakamy et al.

Summary: In this study, preparations of PIC-loaded bilosome-zein (PIC-BZ) were formulated and characterized, and the optimized PIC-BZ showed a higher cytotoxicity against lung cancer cells compared to pure PIC. The PIC-BZ formulation exhibited smaller IC50 values and induced cell apoptosis effectively, as demonstrated by cell cycle analysis and caspase-3 protein expression.

PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders

Rishi Sharma et al.

Summary: The GAL-24 glycodendrimer is designed for targeted drug delivery to hepatocytes by exploiting the asialoglycoprotein receptor 1 (ASGP-R). It demonstrates significant accumulation in the liver shortly after systemic administration and maintains hepatocyte-targeting capabilities in mouse and rat models, showing promise for improved drug delivery in treating various liver disorders.

BIOMACROMOLECULES (2021)

Article Oncology

Conventional myelosuppressive chemotherapy for non-haematological malignancy disrupts the intestinal microbiome

Lito E. Papanicolas et al.

Summary: Conventional myelosuppressive chemotherapy results in significant changes in gut microbiota characteristics during the predicted myelosuppression period post-chemotherapy, but these changes are no longer significant at the end of the chemotherapy cycle. Further research is needed to link microbiome changes during chemotherapy to clinical outcomes.

BMC CANCER (2021)

Article Pharmacology & Pharmacy

Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAFV600E melanoma-bearing mice

Aml Mekkawy et al.

Summary: The study explores the efficacy of a combination therapy of PTX and PD98059 in enhancing cytotoxicity against melanoma cells expressing the BRAF mutation. The use of PD98059-loaded NPs showed superior cellular uptake and cytotoxicity compared to soluble PD98059, suggesting a potential therapeutic approach for improving survival outcomes in patients with metastatic melanoma.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

A Review on Cancer Immunotherapy and Applications of Nanotechnology to Chemoimmunotherapy of Different Cancers

Safiye Akkin et al.

Summary: Variations in cancer treatment approaches exist globally, but cancer remains the second leading cause of death. Immunotherapy and nanotechnology may enhance the efficacy of cancer treatment.

MOLECULES (2021)

Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update post COVID-19 vaccines

Aaron C. Anselmo et al.

Summary: Nanoparticles serve as a crucial technology in treating cancer, imaging tissues, and facilitating vaccination. The recent Emergency Use Authorization of COVID-19 lipid nanoparticle vaccines has highlighted the potential of nanoparticles as delivery vehicles in the forefront of biotechnology.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

Kai Li et al.

Summary: MDSCs are a group of immunosuppressive cells that play a crucial role in tumor progression, affecting tumor development through various pathways and interfering with the efficacy of current anti-tumor therapies. Targeting MDSCs is a promising strategy for future cancer treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

Shun Wang et al.

Summary: Pancreatic cancer is increasingly common and often diagnosed at advanced stages with poor prognosis. Due to its high heterogeneity, metabolic reprogramming, and dense stromal environment, current therapies have limited efficacy. Recent advances in understanding the biology and genetics of pancreatic cancer have led to new clinical therapeutic options.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Lei Zhong et al.

Summary: Targeted therapeutic drugs have become mainstream cancer treatments due to their advantages in efficacy and safety, but still face challenges such as low response rate and drug resistance. A comprehensive review was conducted on small-molecule targeted anti-cancer drugs to promote their development, discussing current challenges and providing insights and perspectives for future research and development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Chemistry, Multidisciplinary

An overview of polymeric nanomicelles in clinical trials and on the market

Xue Zheng et al.

Summary: Polymeric nanomedicine, especially polymeric micelles (PM) with nanoscale size, shows promising physical and biological advantages such as excellent solubility, pharmacokinetics, efficacy, and lower toxicity. PM has garnered increasing interest in research and clinical applications, with good clinical outcomes but also facing challenges.

CHINESE CHEMICAL LETTERS (2021)

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ACTA BIOMATERIALIA (2020)

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Poly(diaminosulfide) Microparticle-Based Vaccine for Delivery of Leptospiral Antigens

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Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functionalnanoparticles

Libo Zhang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells

Nazila Jalilzadeh et al.

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Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model

Ping Zhang et al.

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Multi-mode biodegradable tumour-microenvironment sensitive nanoparticles for targeted breast cancer imaging

Zhenhui Nie et al.

NANOSCALE RESEARCH LETTERS (2020)

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Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies

Frederik Soetaert et al.

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Recent advances in siRNA delivery mediated by lipid-based nanoparticles

Sei Yonezawa et al.

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Biotinylated Streptavidin Surface Coating Improves the Efficacy of a PLGA Microparticle-Based Cancer Vaccine

Brett P. Gross et al.

BIOCONJUGATE CHEMISTRY (2020)

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BIOMEDICINE & PHARMACOTHERAPY (2020)

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Biomarkers for HER2-positive metastatic breast cancer: Beyond hormone receptors

Maria Vittoria Dieci et al.

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Protein-Based Nanoparticles as Drug Delivery Systems

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PHARMACEUTICS (2020)

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Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Applications and Limitations of Dendrimers in Biomedicine

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Progress in Cancer Research, Prevention, and Care

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NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

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Cyclohepta[b]thiophenes as Potential Antiproliferative Agents: Design, Synthesis, In Vitro, and In Vivo Anticancer Evaluation

Somaya A. Abdel-Rahman et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)

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Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review

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NATURE REVIEWS CANCER (2020)

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Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

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FRONTIERS IN PHARMACOLOGY (2019)

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Albumin Nanovectors in Cancer Therapy and Imaging

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BIOMOLECULES (2019)

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Bombesin receptors as potential targets for anticancer drug delivery and imaging

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Development of a ZHER3-Affibody-Targeted Nano-Vector for Gene Delivery to HER3-Overexpressed Breast Cancer Cells

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Annual Review of Physiology (2019)

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Epidermal Growth Factor Receptor and Its Role in Pancreatic Cancer Treatment Mediated by Nanoparticles

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Nanoparticles in the clinic: An update

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Affinity enrichment for mass spectrometry: improving the yield of low abundance biomarkers

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EXPERT REVIEW OF PROTEOMICS (2018)

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

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Manipulating extracellular tumour pH: an effective target for cancer therapy

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RSC ADVANCES (2018)

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Poly(Ethylene Glycol)-Polylactide Micelles for Cancer Therapy

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FRONTIERS IN PHARMACOLOGY (2018)

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Targeting veGF/veGFR to Modulate Antitumor immunity

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FRONTIERS IN IMMUNOLOGY (2018)

Article Pharmacology & Pharmacy

Harnessing albumin as a carrier for cancer therapies

Ella N. Hoogenboezem et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Article Medicine, Research & Experimental

Encapsulation of verapamil and doxorubicin by MPEG-PLA to reverse drug resistance in ovarian cancer

Weiping Zheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biophysics

Extravasation of Brownian Spheroidal Nanoparticles through Vascular Pores

Preyas N. Shah et al.

BIOPHYSICAL JOURNAL (2018)

Review Chemistry, Multidisciplinary

Liposomes and polymersomes: a comparative review towards cell mimicking

Emeline Rideau et al.

CHEMICAL SOCIETY REVIEWS (2018)

Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Review Chemistry, Multidisciplinary

Stress Biomarkers in Biological Fluids and Their Point-of-Use Detection

Andrew J. Steckl et al.

ACS SENSORS (2018)

Article Chemistry, Multidisciplinary

Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo

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JOURNAL OF CONTROLLED RELEASE (2018)

Review Pediatrics

Possible strategies to cross the blood-brain barrier

Cinzia M. Bellettato et al.

ITALIAN JOURNAL OF PEDIATRICS (2018)

Review Materials Science, Multidisciplinary

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

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APPLIED MATERIALS TODAY (2018)

Review Oncology

Every step of the way: integrins in cancer progression and metastasis

Hellyeh Hamidi et al.

NATURE REVIEWS CANCER (2018)

Article Biochemical Research Methods

Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization

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BIOCONJUGATE CHEMISTRY (2017)

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Tracking the dynamics of circulating tumour cell phenotypes using nanoparticle-mediated magnetic ranking

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Dendrimer-based nanocarriers: a versatile platform for drug delivery

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WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2017)

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Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Article Nanoscience & Nanotechnology

Double-receptor-targeting multifunctional iron oxide nanoparticles drug delivery system for the treatment and imaging of prostate cancer

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Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells

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Folic acid-decorated and PEGylated PLGA nanoparticles for improving the antitumour activity of 5-fluorouracil

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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

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ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 18 (2016)

Review Pharmacology & Pharmacy

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

Paola Moreno et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

Article Nanoscience & Nanotechnology

Carbon nanotubes as cancer therapeutic carriers and mediators

Kuk Hui Son et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Article Nanoscience & Nanotechnology

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

Binlong Chen et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

Review Chemistry, Multidisciplinary

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Daniel Bobo et al.

PHARMACEUTICAL RESEARCH (2016)

Article Medicine, Research & Experimental

Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery

Xiao Tong et al.

THERANOSTICS (2016)

Article Nanoscience & Nanotechnology

Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

NATURE REVIEWS MATERIALS (2016)

Article Multidisciplinary Sciences

Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

Zhu Jin et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

Surface Modified Multifunctional and Stimuli Responsive Nanoparticles for Drug Targeting: Current Status and Uses

Panoraia I. Siafaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Chemistry, Multidisciplinary

Spatiotemporal Targeting of a Dual-Ligand Nanoparticle to Cancer Metastasis

Elizabeth Doolittle et al.

ACS NANO (2015)

Review Chemistry, Multidisciplinary

Cancer biomarker detection: recent achievements and challenges

Li Wu et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Pharmacology & Pharmacy

Maltose modified poly(propylene imine) dendrimers as potential carriers of nucleoside analog 5′-triphosphates

Aleksandra Szulc et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Article Chemistry, Physical

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

Alex K. K. Leung et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2015)

Review Biotechnology & Applied Microbiology

Nanotechnology for enrichment and detection of circulating tumor cells

Saheel Bhana et al.

NANOMEDICINE (2015)

Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

Article Biochemistry & Molecular Biology

Insights into bombesin receptors and ligands: Highlighting recent advances

Irene Ramos-Alvarez et al.

PEPTIDES (2015)

Article Chemistry, Medicinal

Novel synthesizing method of pH-dependent doxorubicin-loaded anti-CD22-labelled drug delivery nanosystem

Mengjiao Sun et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Review Biotechnology & Applied Microbiology

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

Arijit Bhowmik et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Surgery

Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis

Sang Hun Lee et al.

ANNALS OF SURGICAL TREATMENT AND RESEARCH (2015)

Review Pharmacology & Pharmacy

Advances and Challenges of Liposome Assisted Drug Delivery

Lisa Sercombe et al.

FRONTIERS IN PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Leukocytes as carriers for targeted cancer drug delivery

Michael J. Mitchell et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

Review Cell Biology

Gene Therapies for Cancer: Strategies, Challenges and Successes

Swadesh K. Das et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

Mechanism-based cancer therapy: resistance to therapy, therapy for resistance

P. Ramos et al.

ONCOGENE (2015)

Article Chemistry, Multidisciplinary

Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways

Mark E. Hwang et al.

PHARMACEUTICAL RESEARCH (2015)

Article Chemistry, Multidisciplinary

Dendron-Based Micelles for Topical Delivery of Endoxifen: A Potential Chemo- Preventive Medicine for Breast Cancer

Yang Yang et al.

ADVANCED FUNCTIONAL MATERIALS (2014)

Article Cell Biology

Changes in cell and tissue organization in cancer of the breast and colon

Lindsay Hinck et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Article Gastroenterology & Hepatology

Cholecystokinin Mediates Progression and Metastasis of Pancreatic Cancer Associated with Dietary Fat

Gail L. Matters et al.

DIGESTIVE DISEASES AND SCIENCES (2014)

Article Chemistry, Multidisciplinary

Enhancing the Efficiency of Gold Nanoparticles Treatment of Cancer by Increasing Their Rate of Endocytosis and Cell Accumulation Using Rifampicin

Moustafa R. K. Ali et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

Liposomes in tissue engineering and regenerative medicine

Nelson Monteiro et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)

Article Biochemistry & Molecular Biology

Overcoming Cancer Multidrug Resistance by Codelivery of Doxorubicin and Verapamil with Hydrogel Nanoparticles

Ming Qin et al.

MACROMOLECULAR BIOSCIENCE (2014)

Article Chemistry, Multidisciplinary

Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

Peipei Zhang et al.

NANOSCALE (2014)

Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

Article Plant Sciences

Folate-modified doxorubicin-loaded nanoparticles for tumor-targeted therapy

Guicun Wu et al.

PHARMACEUTICAL BIOLOGY (2014)

Review Oncology

Passive targeting of nanoparticles to cancer: A comprehensive review of the literature

Remon Bazak et al.

MOLECULAR AND CLINICAL ONCOLOGY (2014)

Review Pharmacology & Pharmacy

Liposomal drug delivery systems: From concept to clinical applications

Theresa M. Allen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Nanoscience & Nanotechnology

Surface Functionalized Gold Nanoparticles for Drug Delivery

Jinping Cheng et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

F-18 Labeled Vasoactive Intestinal Peptide Analogue in the PET Imaging of Colon Carcinoma in Nude Mice

Dengfeng Cheng et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Biotechnology & Applied Microbiology

The Role of Epidermal Growth Factor Receptor in Cancer Metastasis and Microenvironment

Takamitsu Sasaki et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Pharmacology & Pharmacy

The use of lipid-based nanocarriers for targeted pain therapies

Susan Hua et al.

FRONTIERS IN PHARMACOLOGY (2013)

Review Oncology

VEGF targets the tumour cell

Hira Lal Goel et al.

NATURE REVIEWS CANCER (2013)

Article Chemistry, Multidisciplinary

Single-Step Nanoplasmonic VEGF165 Aptasensor for Early Cancer Diagnosis

Hansang Cho et al.

ACS NANO (2012)

Review Pharmacology & Pharmacy

Targeting the EGFR signaling pathway in cancer therapy

Parthasarathy Seshacharyulu et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2012)

Review Immunology

Cancer-associated fibroblasts as targets for immunotherapy

Sunitha Kakarla et al.

IMMUNOTHERAPY (2012)

Article Biochemical Research Methods

Detection of brain tumors using fluorescence diffuse optical tomography and nanoparticles as contrast agents

Pierre-Yves Fortin et al.

JOURNAL OF BIOMEDICAL OPTICS (2012)

Article Chemistry, Multidisciplinary

EGFR-targeted stearoyl gemcitabine nanoparticles show enhanced anti-tumor activity

Michael A. Sandoval et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Review Nanoscience & Nanotechnology

Iron oxide nanoparticles for targeted cancer imaging and diagnostics

Joshua E. Rosen et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

Review Biochemistry & Molecular Biology

Interaction of tumor cells and lymphatic vessels in cancer progression

A. Alitalo et al.

ONCOGENE (2012)

Review Oncology

Targeting of nanoparticles in cancer: drug delivery and diagnostics

Meghna Talekar et al.

ANTI-CANCER DRUGS (2011)

Review Biochemistry & Molecular Biology

Fibroblast growth factors and their receptors in cancer

Jorgen Wesche et al.

BIOCHEMICAL JOURNAL (2011)

Article Engineering, Biomedical

Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery

Jianwei Guo et al.

BIOMATERIALS (2011)

Article Chemistry, Multidisciplinary

Simultaneous Detection of Intracellular Tumor mRNA with Bi-Color Imaging Based on a Gold Nanoparticle/Molecular Beacon

Guangming Qiao et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Article Pharmacology & Pharmacy

Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity

Tae Hyung Kim et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

Article Chemistry, Physical

Folate-functionalized nanoparticles for controlled 5-Fluorouracil delivery

Yan Zhang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2011)

Article Chemistry, Multidisciplinary

Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells

Ming-Jium Shieh et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Somatostatin Receptors as Targets for Nuclear Medicine Imaging and Radionuclide Treatment

Helmut R. Maecke et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

Article Multidisciplinary Sciences

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

Shanta Dhar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Engineering, Chemical

Folate-Receptor-Targeted Delivery of Doxorubicin Using Polyethylene Glycol-Functionalized Gold Nanoparticles

Bahareh Asadishad et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2010)

Article Pharmacology & Pharmacy

VPAC receptor mediated tumor cell targeting by protamine based nanoparticles

Anna Ortner et al.

JOURNAL OF DRUG TARGETING (2010)

Review Oncology

The Role of Fibroblast Growth Factors in Tumor Growth

M. Korc et al.

CURRENT CANCER DRUG TARGETS (2009)

Review Physiology

Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier

Simon C. Satchell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

Article Chemistry, Multidisciplinary

Functionalized nanocompartments (synthosomes) with a reduction-triggered release system

Ozana Onaca et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Review Cell Biology

Tumor lymphangiogenesis and melanoma metastasis

Matthias Rinderknecht et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2008)

Review Chemistry, Multidisciplinary

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

Felix Kratz

JOURNAL OF CONTROLLED RELEASE (2008)

Article Pharmacology & Pharmacy

Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate

Farnaz Esmaeili et al.

JOURNAL OF DRUG TARGETING (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor-positive solid tumors

Ronald E. Fisher et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Chemistry, Multidisciplinary

Functionalized Single-Walled Carbon Nanotubes as Rationally Designed Vehicles for Tumor-Targeted Drug Delivery

Jingyi Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Biochemical Research Methods

Quantum dot-based protein micro- and nanoarrays for detection of prostate cancer biomarkers

Anisha Gokarna et al.

PROTEOMICS (2008)

Article Biotechnology & Applied Microbiology

In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags

Ximei Qian et al.

NATURE BIOTECHNOLOGY (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer

Kaijun Zhang et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Chemistry, Multidisciplinary

Nano-flares: Probes for transfection and mRNA detection in living cells

Dwight S. Seferos et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Cardiac & Cardiovascular Systems

Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis

Ganapati H. Mahabeleshwar et al.

CIRCULATION RESEARCH (2007)

Article Oncology

Folate receptor overexpression is associated with poor outcome in breast cancer

Lynn C. Hartmann et al.

INTERNATIONAL JOURNAL OF CANCER (2007)

Article Chemistry, Multidisciplinary

Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome

Tao Yang et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Article Chemistry, Multidisciplinary

Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle

Wei Lu et al.

JOURNAL OF CONTROLLED RELEASE (2007)

Article Chemistry, Multidisciplinary

Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery

W Lu et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Review Nanoscience & Nanotechnology

Role of nanotechnology in targeted drug delivery and imaging: a concise review

Otilia M. Koo et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2005)

Review Pharmacology & Pharmacy

Pharmacokinetics of pegylated liposomal doxorubicin - Review of animal and human studies

A Gabizon et al.

CLINICAL PHARMACOKINETICS (2003)

Article Oncology

The development and clinical use of trastuzumab (Herceptin)

M Harries et al.

ENDOCRINE-RELATED CANCER (2002)

Article Medicine, General & Internal

Prostate-specificy-antigen testing for early diagnosis of prostate cancer.

MJ Barry

NEW ENGLAND JOURNAL OF MEDICINE (2001)