期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 191, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2022.114590
关键词
Layered double hydroxide; Biopolymer; Nanocomposite; Surface modification; Carrier material
资金
- National Research, Development, and Innovation office [SNN131558]
- Ministry of Innovation and Technology of Hungary [TKP2021-NVA-19]
- University of Szeged Open Access Fund [5767]
Layered double hydroxides (LDHs) have great potential for (bio)medical applications due to their layered morphology, anion exchanging property, and facile surface modification with biopolymers. This review focuses on the advantages of polymer adsorption on LDH surfaces and its effect on the colloidal stability of dispersions. The biocompatibility and biomedical applications of LDH-biopolymer composite materials are discussed, and future research directions are suggested.
Layered double hydroxides (LDHs) are appealing nanomaterials for (bio)medical applications and their potential is threefold. One can gain advantage of the structure of LDH frame (i.e., layered morphology), anion exchanging property towards drugs with acidic character and tendency for facile surface modification with biopolymers. This review focuses on the third aspect, as it is necessary to evaluate the advantages of polymer adsorption on LDH surfaces. Beside the short discussion on fundamental and structural features of LDHs, LDH-biopolymer interactions will be classified in terms of the effect on the colloidal stability of the dispersions. Thereafter, an overview on the biocompatibility and biomedical applications of LDH-biopolymer composite materials will be given. Finally, the advances made in the field will be summarized and future research directions will be suggested. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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