期刊
ACTA PHARMACOLOGICA SINICA
卷 43, 期 12, 页码 3045-3054出版社
NATURE PUBL GROUP
DOI: 10.1038/s41401-022-00976-6
关键词
immunotherapy; nanosized drug delivery systems (NDDSs); immunosuppressive tumor microenvironment (ITME); immunogenetic cell death (ICD); tumor vaccine
资金
- National Natural Science Foundation of China [81871471, 31930066, 32130058, 32171315]
- Natural Science Foundation of Shanghai [19ZR1479900]
- Science and Technology Commission of Shanghai Municipality [19431900800]
- International Partnership Program of CAS [153631KYSB20190013]
- Natural Science Foundation of Shandong [ZR2019ZD25]
- Special Research Assistant Project of CAS
- China Postdoctoral Science Foundation [2020M681428]
- Shanghai Postdoctoral Excellence Program [2020495]
Despite the clinical benefits of immune activation in cancer treatment, the immunosuppressive tumor microenvironment (ITME) poses a major challenge. This review explores strategies using nanosized drug delivery systems (NDDSs) to modulate ITME, including triggering immunogenetic cell death, utilizing tumor vaccines, and directly regulating intratumoral immune components. The contributions and future directions in this field are also discussed.
Immunotherapy that activates immune systems for combating cancer has yielded considerable clinical benefits recently. However, the immunosuppressive tumor microenvironment (ITME) is a major hurdle to immunotherapy as it supports tumor to evade immune surveillance. Reversing ITME facilitates the recruitment and activation of antitumor immune cells, thereby promoting immunotherapy. Our group has developed various nanosized drug delivery systems (NDDSs) to modulate ITME with enhanced efficacy and safety. In the review we introduce the ITME-remodeling strategies for improving immunotherapy based on NDDSs including triggering tumor cells to undergo immunogenetic cell death (ICD), applying tumor vaccine, and directly regulating intratumoral immune components (immune cells or cytokines). In order to guide the design of NDDSs for amplified effects of antitumor immunotherapy, the contributions and future directions of this field are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据