Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses

Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB1R and CB2R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB1R and CB2R and their interaction in the modulation of psychostimulant responses.

Automated summary

Addiction to psychostimulant drugs is a significant public health issue and cannabinoid receptors CB1R and CB2R play a crucial role in modulating the rewarding effects of these drugs. This review summarizes studies on pharmacological intervention targeting CB1R and CB2R and their interaction in psychostimulant responses.