4.6 Article

A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models

Yuanyuan Zhao et al.

Summary: This study identifies ATAD3A oligomerization as a key mechanism causing impaired cholesterol metabolism and neuropathology in AD models. Suppressing ATAD3A oligomerization can reduce pathological changes and cognitive deficits in AD.

NATURE COMMUNICATIONS (2022)

Article Clinical Neurology

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains

Loan Vaillant-Beuchot et al.

Summary: Recent evidence suggests that APP-CTFs may trigger AD pathology, while mitochondrial dysfunction is considered an early event in AD development. Accumulation of APP-CTFs can lead to mitochondrial morphological changes and impaired basal mitophagy, possibly playing a crucial role in AD pathogenesis.

ACTA NEUROPATHOLOGICA (2021)

Article Biochemistry & Molecular Biology

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease

Arubala P. Reddy et al.

Summary: The study found that citalopram has a protective effect against mutant APP, Aβ, and mitochondrial toxicities, suggesting a potential neuroprotective role in patients with depression, anxiety, and AD.

HUMAN MOLECULAR GENETICS (2021)

Article Clinical Neurology

A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies

Yinan Yao et al.

Summary: The truncated APP C586-695 fragment binds directly to the inflammatory transcription factor CEBPB, enhancing its transcriptional activity and exacerbating Alzheimer's disease-related gene expression and pathogenesis.
Article Immunology

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease

Peng Xu et al.

Summary: Research has shown that GSAP plays important roles in Alzheimer's disease and Down's syndrome by regulating multiple biological pathways including protein phosphorylation, trafficking, lipid metabolism, and mitochondrial function. GSAP physically interacts with the Fe65-APP complex to regulate APP trafficking/partitioning, is enriched in the mitochondria-associated membrane, and affects lipid homeostasis through the amyloidogenic processing of APP. Deletion of GSAP can lead to an unfavorable lipid environment for AD pathogenesis, improved mitochondrial function, and rescue of cognitive deficits in an AD mouse model.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Review Neurosciences

Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

Bing Bai et al.

Summary: Mass spectrometry-based proteomics plays a crucial role in Alzheimer's disease research, allowing for in-depth analysis of proteome and protein post-translational modifications. Studies have revealed not only known amyloid and tau pathways, but also novel protein networks in AD. Meta-analysis of deep datasets has identified a large number of differentially expressed proteins in the AD brain proteome, indicating the involvement of diverse cell types in Alzheimer's pathology.

MOLECULAR NEURODEGENERATION (2021)

Article Biochemistry & Molecular Biology

Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

Junhui Tang et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Clinical Neurology

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

Maria Pulina et al.

ALZHEIMERS & DEMENTIA (2020)

Article Biochemistry & Molecular Biology

Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner

Arun Kumar Kondadi et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

David A. Hicks et al.

BIOSCIENCE REPORTS (2020)

Review Neurosciences

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

Ian W. Weidling et al.

EXPERIMENTAL NEUROLOGY (2020)

Article Biochemistry & Molecular Biology

The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking

Jorge Montesinos et al.

EMBO JOURNAL (2020)

Review Pharmacology & Pharmacy

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

Judit M. Perez Ortiz et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Neurosciences

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Ying Jiang et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions

Pei-I Tsai et al.

MOLECULAR CELL (2018)

Review Neurosciences

Imaging the evolution and pathophysiology of Alzheimer disease

William Jagust

NATURE REVIEWS NEUROSCIENCE (2018)

Review Cell Biology

The MICOS complex of human mitochondria

Vera Kozjak-Pavlovic

CELL AND TISSUE RESEARCH (2017)

Article Neurosciences

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

Dolores Del Prete et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Amyloid precursor protein processing and bioenergetics

Heather M. Wilkins et al.

BRAIN RESEARCH BULLETIN (2017)

Article Biochemistry & Molecular Biology

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization

H. Li et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Clinical Neurology

Molecular Basis of Familial and Sporadic Alzheimer's Disease

Jolanta Dorszewska et al.

CURRENT ALZHEIMER RESEARCH (2016)

Article Cell Biology

MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria

Mari J. Aaltonen et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Geriatrics & Gerontology

CHCHD2 gene mutations in familial and sporadic Parkinson's disease

Chang-he Shi et al.

NEUROBIOLOGY OF AGING (2016)

Article Multidisciplinary Sciences

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

Valentina Cappello et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

APP intracellular domain-WAVE1 pathway reduces amyloid-β production

Ilaria Ceglia et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure

Chengli Ding et al.

SCIENTIFIC REPORTS (2015)

Article Multidisciplinary Sciences

Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation

Rui-Feng Yang et al.

SCIENTIFIC REPORTS (2015)

Article Medicine, General & Internal

Alzheimer's disease

Colin L. Masters et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Neurosciences

Single App knock-in mouse models of Alzheimer's disease

Takashi Saito et al.

NATURE NEUROSCIENCE (2014)

Review Genetics & Heredity

Epigenetic regulation of cholesterol homeostasis

Steve Meaney

FRONTIERS IN GENETICS (2014)

Article Biochemistry & Molecular Biology

A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1

Thorsten Mueller et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Review Neurosciences

Mitochondria-associated ER membranes in Alzheimer disease

Eric A. Schon et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2013)

Review Biochemistry & Molecular Biology

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

Russell H. Swerdlow

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Clinical Neurology

AICD Nuclear Signaling and Its Possible Contribution to Alzheimer's Disease

Uwe Konietzko

CURRENT ALZHEIMER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Estela Area-Gomez et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

CHCM1/CHCHD6, Novel Mitochondrial Protein Linked to Regulation of Mitofilin and Mitochondrial Cristae Morphology

Jie An et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

The physiology of the beta-amyloid precursor protein intracellular domain AICD

Raphaelle Pardossi-Piquard et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Article Neurosciences

Impaired β-Amyloid Secretion in Alzheimer's Disease Pathogenesis

Davide Tampellini et al.

JOURNAL OF NEUROSCIENCE (2011)

Review Cell Biology

Mitochondrial accumulation of APP and A beta: significance for Alzheimer disease pathogenesis

Pavel F. Pavlov et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Review Biochemistry & Molecular Biology

Cyp46 Polymorphisms in Alzheimer's Disease: A Review

Analia Nusya Medeiros Garcia et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2009)

Article Biochemical Research Methods

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

Mariusz R. Wieckowski et al.

NATURE PROTOCOLS (2009)

Article Clinical Neurology

Functional Role of Lipoprotein Receptors in Alzheimers Disease

Claus Pietrzik et al.

Current Alzheimer Research (2008)

Article Biochemistry & Molecular Biology

Mitochondrial Aβ:: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

C Caspersen et al.

FASEB JOURNAL (2005)

Review Biochemistry & Molecular Biology

Cholesterol homeostasis and function in neurons of the central nervous system

FW Pfrieger

CELLULAR AND MOLECULAR LIFE SCIENCES (2003)