Combination wound healing using polymer entangled porous nanoadhesive hybrids with robust ROS scavenging and angiogenesis properties

Nanoadhesives can achieve tight wound closure by connecting biomacromolecules from both sides. How-ever, previously developed adhesive systems suffered from suboptimal wound healing efficiency due to the lack of interparticle cohesion, sufficient reactive oxygen species (ROS)-scavenging sites, and angiogen-esis consideration. Herein, we developed a polymer entangled porous nanoadhesive system to address the above challenge by synergy of three functional components. Firstly, hybrid mesoporous silica nanoparti-cles with highly integrated polydopamine (MS-PDA) were prepared by templated synthesis. The entan-gling between PVA polymer and MS-PDA contributed to much stronger cohesion between nanoparticles, which led to 75% larger adhesion strength. As confirmed by in vitro and in vivo evaluations, the highly exposed catechol groups boosted the scavenging activity of ROS (1.8-4.1 fold enhancement as compared with nonporous counterpart). Consequently, more macrophages exhibited anti-inflammatory phenotype, leading to 2-2.6 fold lower pro-inflammatory cytokine levels. Moreover, the sustained release of bioac-tive SiO4 4 - by the disintegration of nanoparticles contributed to similar to 3-fold higher expression of VEGF and enhanced new blood vessel formation, as well as better wound repair. This platform can provide a new paradigm for developing multifunctional nanoadhesive systems in treating skin wounds.

Automated summary

The development of nanoadhesives has successfully addressed the shortcomings of previous adhesive systems in wound healing efficiency. This is achieved by synergistically combining functional components to enhance interparticle cohesion, boost reactive oxygen species scavenging activity, and promote angiogenesis. This system holds great potential for the treatment of skin wounds.