4.8 Article

A Cell Space Station for Spatiotemporal Molecular Manipulation of Immune Checkpoint

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

PROTAC targeted protein degraders: the past is prologue

Miklos Bekes et al.

Summary: Targeted protein degradation (TPD) is a new therapeutic modality that can tackle disease-causing proteins which are difficult to target with conventional small molecules. PROTAC molecules, utilizing the ubiquitin-proteasome system to degrade target proteins, has achieved clinical proof-of-concept and attracted significant industry activity. Future directions include identifying target classes suitable for TPD, expanding the use of ubiquitin ligases for precision medicine, and extending the modality beyond oncology.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Chemistry, Multidisciplinary

Combating Cancer Stem-Like Cell-Derived Resistance to Anticancer Protein by Liposome-Mediated Acclimatization Strategy

Shiyang Shen et al.

Summary: This study reports a liposome-mediated strategy to overcome the resistance of cancer stem cells (CSCs) to TRAIL. This strategy coencapsulates plasmid DNA encoding TRAIL and salinomycin in liposomal assemblies, which enables cancer cells to express TRAIL and sensitizes CSCs to TRAIL-induced apoptosis by upregulating DR expression on CSCs.

NANO LETTERS (2022)

Review Oncology

Programmed cell death 1 ligand 1 signals in cancer cells

Anand V. R. Kornepati et al.

Summary: The understanding of cancer cell-intrinsic PDL1 signals has expanded our knowledge of tumor growth, treatment resistance, and potential biomarkers, providing new opportunities for drug discovery and treatment response evaluation.

NATURE REVIEWS CANCER (2022)

Article Chemistry, Multidisciplinary

Covalent Cell Surface Conjugation of Nanoparticles by a Combination of Metabolic Labeling and Click Chemistry

Alexander Lamoot et al.

Summary: Conjugation of nanoparticles to living cells can be achieved through either covalent or non-covalent reactions, with covalent conjugation resulting in a permanent bound state. Challenges with non-covalent conjugation include dynamic equilibrium between bound and unbound states. Researchers have developed a 2-step click conjugation sequence to address the need for efficient covalent cell surface conjugation, resulting in highly specific binding with low non-specific background.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

Adam D. Cotton et al.

Summary: AbTACs are fully recombinant bispecific antibodies that recruit membrane-bound E3 ligases for the degradation of cell-surface proteins. This new archetype represents a method within the PROTAC field to target cell-surface proteins with fully recombinant biological molecules.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets

Trixy Fang et al.

Summary: The spatial organization of PD-L1 plays a crucial role in regulating T-cell signaling, with PD-L1 ligands at 200 nm distance being more effective in inhibiting T-cell activation and reducing IL-2 expression compared to closer distances. These findings may guide the development of nanomedicine-based immunomodulatory therapies in the future.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

Heng Zhang et al.

Summary: The study introduces a covalent nanobody-based PROTAC strategy named GlueTAC for targeted membrane protein degradation with high specificity and efficiency. By developing a mass-spectrometry-based screening platform, a covalent nanobody (GlueBody) was created for proximity-enabled cross-linking with surface antigens on cancer cells, leading to the internalization and degradation of PD-L1 by the resulting GlueTAC chimera.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Chemistry, Multidisciplinary

A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications

Kiall F. Suazo et al.

Summary: This review discusses the attachment of hydrophobic groups to proteins through different chemical linkages, as well as the use of click chemistry in studying protein lipid modification. It also explores the various types of protein lipid modifications in biology, and the role of click chemistry in identifying lipid-modified proteins, studying their regulation, and their involvement in diseases. Additionally, the review covers the use of protein-lipid modifying enzymes for specific labeling applications.

CHEMICAL REVIEWS (2021)

Article Multidisciplinary Sciences

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

Youqian Wu et al.

Summary: The study identifies compounds inducing PD-L1 degradation, with EGFR inhibitors promoting PD-L1 degradation through GSK3 alpha-mediated phosphorylation. ARIH1 is identified as the E3 ubiquitin ligase targeting PD-L1 for degradation and plays a critical role in anti-tumor immunity. This research suggests that GSK3 alpha and ARIH1 may be potential drug targets to enhance anti-tumor immunity and immunotherapies.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Analytical

Living-System-Driven Evolution of Self-Assembled-Peptide Probes: For Boosting Glioma Theranostics

Mingmei Guo et al.

Summary: The article introduces a directed evolution strategy combining high-content screening from living systems and artificial modification to discover totipotential peptides, ultimately enabling high-resolution molecular imaging and therapy.

ANALYTICAL CHEMISTRY (2021)

Article Biophysics

Multi-stage responsive peptide nanosensor: Anchoring EMT and mitochondria with enhanced fluorescence and boosting tumor apoptosis

Yuwei Tian et al.

Summary: Epithelial-mesenchymal transition (EMT) is closely related to tumor metastasis and invasion, with mesenchymal tumor mitochondria being a critical target for tumor inhibition. Real-time monitoring of EMT and inhibiting mesenchymal tumor mitochondria is crucial for diagnosis and therapy. The NDRP nano biosensor has been designed to specifically recognize and damage mesenchymal tumor cells in vivo, serving as a promising theranostic platform for targeted tumor treatment.

BIOSENSORS & BIOELECTRONICS (2021)

Article Chemistry, Multidisciplinary

Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy

Yu Yang et al.

Summary: The development of an aptamer-based logic computing reaction allows for precise and sustained immune checkpoint blockade therapy on the surface of cancer cells without the need for antibodies. Using a bioorthogonal reaction, aptamers are conjugated on the living cell surface to trigger a T cell-mediated antitumor immunotherapy, significantly prolonging overall mouse survival.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Multidisciplinary Sciences

WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression

Man Wu et al.

Summary: The study reveals a tumor suppressor role for WSX1 in hepatocytes independent of IL-27, showing that WSX1 inhibits tumor progression by downregulating PD-L1 expression and enhancing CD8(+) T cell-mediated anti-tumor immune responses in the liver.

NATURE COMMUNICATIONS (2021)

Editorial Material Biotechnology & Applied Microbiology

Trends in clinical development for PD-1/PD-L1 inhibitors

Jia Xin Yu et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Biochemistry & Molecular Biology

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

Elliot A. Philips et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Lysosome-targeting chimaeras for degradation of extracellular proteins

Steven M. Banik et al.

NATURE (2020)

Article Engineering, Biomedical

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

Han Yao et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Chemistry, Multidisciplinary

Deep Tumor Penetration of Drug-Loaded Nanoparticles by Click Reaction-Assisted Immune Cell Targeting Strategy

Soo Hong Lee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Biotechnology & Applied Microbiology

Targeted protein degradation: expanding the toolbox

Matthieu Schapira et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Multidisciplinary Sciences

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery

Shaogeng Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

HIP1R targets PD-L1 to lysosomal degradation to alter T cell-mediated cytotoxicity

Huanbin Wang et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

A Ligand System for the Flexible Functionalization of Quantum Dots via Click Chemistry

Yue Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Chemistry, Multidisciplinary

Visualizing biologically active small molecules in cells using click chemistry

Tatiana Caneque et al.

NATURE REVIEWS CHEMISTRY (2018)

Article Multidisciplinary Sciences

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L. Burr et al.

NATURE (2017)

Article Multidisciplinary Sciences

PD-1/PD-L1 binding studies using microscale thermophoresis

Romain Magnez et al.

SCIENTIFIC REPORTS (2017)

Article Oncology

PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer

Jennifer H. Yearley et al.

CLINICAL CANCER RESEARCH (2017)

Editorial Material Chemistry, Medicinal

The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery

Dong Guo et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Review Oncology

The dynamic control of signal transduction networks in cancer cells

Walter Kolch et al.

NATURE REVIEWS CANCER (2015)

Article Chemistry, Multidisciplinary

Synthetic Self-Localizing Ligands That Control the Spatial Location of Proteins in Living Cells

Manabu Ishida et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Review Cell Biology

Signalling ballet in space and time

Boris N. Kholodenko et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Multidisciplinary Sciences

The promises and pitfalls of RNA-interference-based therapeutics

Daniela Castanotto et al.

NATURE (2009)

Review Multidisciplinary Sciences

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

John D. Scott et al.

SCIENCE (2009)

Article Biotechnology & Applied Microbiology

Opinion - Drug-target residence time and its implications for lead optimization

Robert A. Copeland et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Immunology

PD-L2 is a second ligand for PD-I and inhibits T cell activation

Y Latchman et al.

NATURE IMMUNOLOGY (2001)