期刊
ACS NANO
卷 16, 期 11, 页码 18503-18514出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c06705
关键词
IBD monitoring; orally administered nanosensor; synthetic biomarker; point of care testing; microfluidic chip
类别
资金
- National Key Ramp
- D Program of China [2019YFA0709200]
- National Nature Science Foundation of China [21874066]
- Fundamental Research Funds for Central Universities
- Natural Science Foundation of Jiangsu Province [BK20200336]
- Key Research and Development Program of Jiangsu Province [BE2021373]
- Program for Innovative Talents and Entrepreneur in Jiangsu
- Postgraduate Research amp
- Practice Innovation Program of Jiangsu Province [KYCV20_0036]
Inflammatory bowel disease (IBD) is a chronic autoimmune disease with increasing incidence globally. This study presents an orally administered nanosensor that releases ultrasmall platinum nanoclusters (PtNCs) in IBD-related inflammatory environments, enabling non-invasive monitoring and diagnosis.
Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune disease with rising incidence worldwide. There is an increasing desire for non-invasive diagnostic tools to enable simple and sensitive IBD monitoring. Here, we report an orally administered nanosensor which will dissociate into ultrasmall platinum nanoclusters (PtNCs) in IBD-related inflammatory microenvironments. By exploiting the enzyme-mimicking activity of PtNCs and the precise bandpass filterability of kidney, the released-PtNCs can be detected in a scalable urinary readout, such as fluorescence and volumetric bar-chart chip (V Chip), for point-of-care (POC) analysis. Our results demonstrate that the nanosensors exhibit significant signal differences between IBDmodel mice and healthy mice, which is more sensitive than clinical ELISA assay based on fecal calprotectin. Such a non-invasive diagnostic modality significantly assists in the personalized assessment of pharmacological and follow-up efficacy. We envision that this modular conception will promote the rapid diagnosis of diverse diseases by changing specific responsive components.
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