期刊
ACS NANO
卷 16, 期 9, 页码 13430-13467出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c04756
关键词
biomaterials; graphene; electrodes; glial reaction; nanocarriers; neural cells; neural stimulation; scaffolds; spinal cord injury; tissue engineering
类别
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/130287/2017]
- MICIN/AEI [PID2020-113480RB-I00]
- NeuroStimSpinal Project - European Union [829060]
- Centro Portugal Regional Operational Programme (Centro2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund [CENTRO-01-0145FEDER-022083]
- [UIDB/00481/2020]
- [UIDP/00481/2020-FCT]
This article provides an overview of the potential application of graphene-based materials in the treatment of spinal cord injury (SCI), discussing ongoing clinical trials and the importance of graphene technology in various therapeutic approaches. It also proposes future directions and key points for achieving clinical significance.
Along with the development of the next generation of biomedical platforms, the inclusion of graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential to nourish topmost neuroprotective and neuroregenerative strategies for enhancing neural structural and physiological recovery. In the context of SCI, contemplated as one of the most convoluted challenges of modern medicine, this review first provides an overview of its characteristics and pathophysiological features. Then, the most relevant ongoing clinical trials targeting SCI, including pharmaceutical, robotics/neuromodulation, and scaffolding approaches, are introduced and discussed in sequence with the most important insights brought by GBMs into each particular topic. The current role of these nanomaterials on restoring the spinal cord microenvironment after injury is critically contextualized, while proposing future concepts and desirable outputs for graphene-based technologies aiming to reach clinical significance for SCI.
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