Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

Review Chemistry, Inorganic & Nuclear

Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases

Shuai Zhou et al.

Summary: Recent advances in biomedical nanotechnology have led to the development of drug delivery systems based on mesoporous silica nanoparticles, which have the potential as multifunctional delivery platforms for treating various diseases.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Pharmacology & Pharmacy

Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy

Jiayi Ye et al.

Summary: A bispecific prodrug nanoparticle was engineered to target multiple immune resistance mechanisms in tumor cells and improve cancer immunotherapy. The nanoparticle combines photodynamic therapy (PDT) to induce immunogenic cell death, providing a novel strategy for blocking immune evasion pathways.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Oncology

The In-Vitro Antitumor Effects of AST-3424 Monotherapy and Combination Therapy With Oxaliplatin or 5-Fluorouracil in Primary Liver Cancer

Yu Zhang et al.

Summary: This study explored the in-vitro antitumor activity and mechanism of AST-3424 monotherapy and combination therapy with oxaliplatin (OXA) or 5-fluorouracil (5-Fu). The results showed that AST-3424 had significant inhibiting effects on HCC cells and had higher sensitivity in HepG2 cells. AST-3424 monotherapy and combination therapy with OXA or 5-Fu strongly inhibited the proliferation of HCC cells, induced apoptosis, and suppressed cell migration. The combination with OXA resulted in a synergistic effect. The study suggests that AST-3424 has potential antitumor effects and further studies are needed.

FRONTIERS IN ONCOLOGY (2022)

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Review Chemistry, Multidisciplinary

Stimulus-responsive self-assembled prodrugs in cancer therapy

Xiao Dong et al.

Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.

CHEMICAL SCIENCE (2022)

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Review Oncology

Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms

Gang Li et al.

Summary: This article discusses the importance of natural products from plants and associated microorganisms in the discovery of anticancer drugs, and introduces the application of artificial intelligence techniques in this field.

TRENDS IN CANCER (2022)

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Review Chemistry, Multidisciplinary

Conquering the Hypoxia Limitation for Photodynamic Therapy

Yilin Wan et al.

Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy

Yuanyuan Yang et al.

Summary: A multifunctional light-activatable liposome has been engineered for repetitive on-demand drug release under discontinuous light irradiation, allowing for chemo-photodynamic therapy and immunopotentiation in hypoxic tumors. This system effectively remodels the redox balance in tumors, alleviating hypoxia and enhancing PDT efficacy, reversing cisplatin resistance, and polarizing tumor-associated macrophages to the immunocompetent M1 phenotype.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy

Xiaoyu Xu et al.

Summary: A tailored ROS-activatable self-amplifying supramolecular nanoprodrug was developed for reinforced ROS-responsiveness and highly selective antitumor therapy, showing remarkable in vivo antitumor efficacy with minimal systemic toxicity. The nanoformulation exhibited high stability, beneficial tumor targeting capacity, and pH/ROS-responsiveness, providing an inspirational strategy for exploiting novel ROS-responsive nanoplatform with reinforced responsiveness and specificity for future clinical translation.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Mitochondrial-targeting nanoprodrugs to mutually reinforce metabolic inhibition and autophagy for combating resistant cancer

Min Sun et al.

Summary: This study developed a novel strategy to enhance tumor killing efficacy and combat resistant cancer by mutually reinforcing metabolic inhibition and autophagy. The FG/T-Nanoprodrug, assembled with various functional molecules, demonstrated effective mitochondrial targeting and metabolic inhibition in resistant cancer cells. Through the enhanced chemodynamic therapy, the FG/T-Nanoprodrug was able to induce high levels of autophagy and effectively kill resistant cancer cells in both in vitro and in vivo settings.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Injectable multi-responsive micelle/nanocomposite hybrid hydrogel for bioenzyme and photothermal augmented chemodynamic therapy of skin cancer and bacterial infection

Hua Zheng et al.

Summary: An activatable theranostic strategy, combining bioenzyme and photothermal augmented chemodynamic therapy, was successfully developed for effective treatment of skin tumor and bacterial infection, demonstrating promising potential for simultaneous skin cancer therapy and antibacterial treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells

Shiyang Shen et al.

Summary: This study presents a nanoparticle-based strategy for killing CSCs in tumors by inducing CSC differentiation with all-trans retinoic acid release under hypoxic conditions and triggering cell death with camptothecin release in response to increasing reactive oxygen species levels in differentiating CSCs.

NATURE NANOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

Fang Sun et al.

Summary: The study presents a novel strategy to enhance photoimmunotherapy of pancreatic cancer by provoking T cells activation and overcoming adaptive immune resistance.

ADVANCED SCIENCE (2021)

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Article Pharmacology & Pharmacy

Pharmacokinetics and Safety of Fosaprepitant Dimeglumine in Healthy Chinese Volunteers: Bioequivalence Study

Kang Lu et al.

Summary: This study demonstrated the bioequivalence of intravenously administered Fosaprepitant dimeglumine (FD) in comparison to the reference product. The study involved healthy volunteers (HVs) and found no serious adverse events associated with the test product. This suggests that FD may be a safer alternative for chemotherapy-induced nausea and vomiting.

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2021)

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Article Nanoscience & Nanotechnology

Optimized Combination of Photodynamic Therapy and Chemotherapy Using Gelatin Nanoparticles Containing Tirapazamine and Pheophorbide a

Donghyun Lee et al.

Summary: This study developed nanoparticles containing Pba and TPZ for combination therapy, successfully suppressing tumor growth in vivo through the synergetic effects and efficient drug delivery. The results suggest that in vitro screening based on CI values, mechanism studies, and real-time in vivo imaging are promising strategies for developing optimized combination therapy nanoparticles.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Floxuridine Oligomers Activated under Hypoxic Environment

Kunihiko Morihiro et al.

Summary: This study reported the design and synthesis of floxuridine oligomer prodrugs, which are active under hypoxia conditions, can suppress tumor growth, and exhibit lower cytotoxicity. This is the first demonstration of conditional control of the medicinal efficacy of oligomerized nucleoside anticancer drugs.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

Mechanochemical bond scission for the activation of drugs

Shuaidong Huo et al.

Summary: This study demonstrated the potential of ultrasound to activate mechanoresponsive prodrug systems by controlled scission of covalent and non-covalent bonds, releasing various drugs and showing a promising new strategy for drug activation.

NATURE CHEMISTRY (2021)

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Article Engineering, Biomedical

Tumor Microenvironment Triggered Cascade-Activation Nanoplatform for Synergistic and Precise Treatment of Hepatocellular Carcinoma

Fuli Xin et al.

Summary: The study utilizes the A-NPLap/TPZ nanoplatform as a novel approach for the synergistic therapy of HCC, inducing tumor cell apoptosis and inhibiting tumor growth by releasing beta-Lap and TPZ through targeting effect.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

Xiaotong Cheng et al.

Summary: Overexpression of glutathione in cancer cells leads to resistance to anticancer therapies, making GSH depletion a potential target for cancer treatments. By combining with mainstream cancer therapies, GSH-depleting agents can enhance cancer cells responses to cell death stimuli.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

In Situ Supramolecular Self-Assembly of Pt(IV) Prodrug to Conquer Cisplatin Resistance

Qian Wang et al.

Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy

Yanli Li et al.

Summary: The ZIF-82-PVP nanoparticles can effectively promote apoptosis of hypoxic prostate cancer cells under X-ray irradiation by inhibiting autophagy and inducing nitrosative stress.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Editorial Material Oncology

Use of Uridine Triacetate to Reverse Severe Persistent Myelosuppression Following 5-fluorouracil Exposure in a Patient With a c.557A>G Heterozygous DPYD Variant

Michael Leung et al.

Summary: Delayed severe toxicities may occur in patients with heterozygous DPYD mutation genotypes, particularly those of African descent and female sex, after exposure to fluoropyrimidine. Treatment with uridine triacetate should not be restricted to patients with early-onset fluoropyrimidine toxicities or homozygous DPYD mutations.

CLINICAL COLORECTAL CANCER (2021)

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Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery

Lei Ge et al.

Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.

NANO LETTERS (2021)

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Review Pharmacology & Pharmacy

The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy

Yue Li et al.

Summary: Hypoxia is a key feature of most solid tumors, making them resistant to radiation and chemotherapy, but can be targeted with hypoxia-activated prodrugs. TH-302, a well-studied HAP, shows promising efficacy in preclinical and clinical studies, suggesting potential for future research directions.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Enamine N-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents

Dahye Kang et al.

Summary: Tumor hypoxia-induced adaptive reprogramming of cancer cells can lead to poor prognosis, making hypoxia-activated prodrug development challenging. A novel hypoxia-responsive trigger derived from enamine N-oxide structures was synthesized and applied for hypoxia-activated prodrug and tumor labeling. The versatile enamine N-oxide motif with dual drug release and imaging modalities presents an attractive opportunity for theranostic development to address the needs for new therapeutics and patient stratification.

ACS CENTRAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer

Fengqi Zhou et al.

Summary: This research addresses the issue of immune evasion in T-cell-based cancer immunotherapy by developing a multifunctional prodrug nanovesicle. By enhancing tumor antigen presentation and the infiltration of T lymphocytes, the prodrug nanovesicles demonstrate efficacy in overcoming immune resistance and potentiate tumor immunotherapy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Acidity-Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

Rundi Song et al.

Summary: Researchers have developed a immunotherapy method that enhances the immunogenicity of tumor cells by inducing ferroptosis, thereby improving the efficacy of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Selective Thrombosis of Tumor for Enhanced Hypoxia-Activated Prodrug Therapy

Zhaoyu Ma et al.

Summary: The study presents a strategy of using selective tumor thrombus inducing hypoxia activation therapy to improve the therapeutic index of coagulation-based tumor therapy, which selectively activates thrombosis and increases hypoxia levels for enhanced treatment outcomes.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

One-stitch bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules

Liang Wang et al.

Summary: Bioorthogonal prodrug activation is achieved using a new two-component nanosystem based on cross-linked lipoic acid nanocapsules, which shows improved anticancer effect and selective accumulation within tumor tissue, marking a significant advancement in targeted cancer therapy.

BIOMATERIALS (2021)

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Editorial Material Oncology

Tumor heterogeneity

Dana Pe'er et al.

Summary: Tumor heterogeneity has expanded beyond genetic terms and now encompasses multiple facets. These facets pose a challenge in understanding cancer etiology, but also present an opportunity to comprehend prognosis and therapy response.

CANCER CELL (2021)

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Review Chemistry, Inorganic & Nuclear

Strategies for combining triplet-triplet annihilation upconversion sensitizers and acceptors in a host matrix

Waqas Ahmad et al.

Summary: This review article summarizes the latest advances in triplet-triplet annihilation upconversion (TTA-UC), covering aspects such as substrate patterns, excited-state engineering, and potential applications, aiming to extend the research scope of this technology.

COORDINATION CHEMISTRY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Noncanonical Amino Acids for Hypoxia-Responsive Peptide Self-Assembly and Fluorescence

Binbin Hu et al.

Summary: The design of endogenous stimuli-responsive amino acids allows for precise modulation of proteins or peptides under a biological microenvironment, as demonstrated in the development of efficient hypoxia imaging probes using a noncanonical amino acid. The unique properties of the synthesized amino acid facilitate the creation of aromatic peptides undergoing NTR-responsive self-assembly, leading to the development of morphology-transformable supramolecular probes for imaging hypoxic tumor cells. This versatile amino acid provides a powerful toolkit for synthetic biology and the creation of novel biomaterials responsive to biological environments.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Chemistry, Multidisciplinary

GSH-Responsive Nanoprodrug to Inhibit Glycolysis and Alleviate Immunosuppression for Cancer Therapy

Xiaohan Liu et al.

Summary: The study synthesized a nanoprodrug that can inhibit glycolysis of cancer cells and alleviate the immunosuppressive microenvironment by releasing two drugs, which increased intracellular oxidative stress and induced immunogenic cell death of cancer cells. This strategy opens up new possibilities for exploring dimeric prodrugs for synergistic cancer therapy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Switching on prodrugs using radiotherapy

Jin Geng et al.

Summary: The article introduces a chemistry-based strategy for simultaneous chemo-radiotherapy by activating cancer prodrugs through irradiation, enabling site-directed chemotherapy instead of systemic chemotherapy, which opens up a new era in targeted and directed chemotherapy.

NATURE CHEMISTRY (2021)

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Review Chemistry, Multidisciplinary

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Yuezhou Zhang et al.

Summary: The article discusses the development of nanoprodrug fabrication, which combines prodrug concepts with nanotechnology to enhance cancer treatment. By utilizing the tumor microenvironment and external stimulation, prodrugs can release bioactive drugs at specific sites to reduce systemic toxicity. Nanotechnology, which manipulates matter on a nanoscale, is widely used in cancer therapy and when combined with prodrug strategies, it creates a highly camouflaged Trojan horse for combating cancer threats.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release

Zhiyuan Shi et al.

Summary: A novel ultrasound-responsive release system has been developed to achieve spatiotemporal control over drug activity and enable real-time tracking of drug release and uptake, potentially useful for therapeutic applications and fluorescence imaging.

CHEMICAL SCIENCE (2021)

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Review Chemistry, Multidisciplinary

New Designs for Phototherapeutic Transition Metal Complexes

Cinzia Imberti et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biotechnology & Applied Microbiology

β-Galactosidases: A great tool for synthesizing galactose-containing carbohydrates

Lili Lu et al.

BIOTECHNOLOGY ADVANCES (2020)

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Review Polymer Science

Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications

Zhengyu Deng et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Long-Circulating Drug-Dye-Based Micelles with Ultrahigh pH-Sensitivity for Deep Tumor Penetration and Superior Chemo-Photothermal Therapy

Cunfeng Song et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Engineering Stimuli-Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy

Bo Hou et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Acid-Triggered Release of Native Gemcitabine Conjugated in Polyketal Nanoparticles for Enhanced Anticancer Therapy

Haiping Zhong et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Length effect of stimuli-responsive block copolymer prodrug filomicelles on drug delivery efficiency

Wendong Ke et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Nanoscience & Nanotechnology

Glutathione-Specific and Intracellularly Labile Polymeric Nanocarrier for Efficient and Safe Cancer Gene Delivery

Guowei Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

ROS-Responsive Nanoparticles Formed from RGD-Epothilone B Conjugate for Targeted Cancer Therapy

Xuelin Xia et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Multidisciplinary Sciences

Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

Yifan Zhang et al.

SCIENCE BULLETIN (2020)

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Article Multidisciplinary Sciences

Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Wei Zhang et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism

Zhiqin Deng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

A Self-Evaluating Photothermal Therapeutic Nanoparticle

Yanfang Wang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

pH/Cathepsin B Hierarchical-Responsive Nanoconjugates for Enhanced Tumor Penetration and Chemo-Immunotherapy

Hongliang Du et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Environmental

Tumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapy

Xuemei Yao et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Chemistry, Inorganic & Nuclear

BODI-Pt, a Green-Light-Activatable and Carboplatin-Based Platinum(IV) Anticancer Prodrug with Enhanced Activation and Cytotoxicity

Houzong Yao et al.

INORGANIC CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

Jianzhi Zhu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

Jimei Zhang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Photoactivated Nanosheets Accelerate Nucleus Access of Cisplatin for Drug-Resistant Cancer Therapy

Fang Gao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Fighting against Drug-Resistant Tumors using a Dual-Responsive Pt(IV)/Ru(II) Bimetallic Polymer

Xiaolong Zeng et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Paclitaxel Prodrug Activatable by Irradiation in a Hypoxic Microenvironment

Shiyu Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy

Na Yu et al.

NANO LETTERS (2020)

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Review Chemistry, Multidisciplinary

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Fei Gong et al.

NANO TODAY (2020)

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Article Chemistry, Multidisciplinary

Dual pH/ROS-Responsive Nanoplatform with Deep Tumor Penetration and Self-Amplified Drug Release for Enhancing Tumor Chemotherapeutic Efficacy

Yongfei Li et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Acid-sensitive PEGylated paclitaxel prodrug nanoparticles for cancer therapy: Effect of PEG length on antitumor efficacy

Jingqing Mu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Toward Drug Release Using Polymer Mechanochemical Disulfide Scission

Zhiyuan Shi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Probing the Superiority of Diselenium Bond on Docetaxel Dimeric Prodrug Nanoassemblies: Small Roles Taking Big Responsibilities

Shiyi Zuo et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Precisely Structured Nitric-Oxide-Releasing Copolymer Brush Defeats Broad-Spectrum Catheter-Associated Biofilm Infections In Vivo

Zheng Hou et al.

ACS CENTRAL SCIENCE (2020)

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Article Multidisciplinary Sciences

Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Yinxian Yang et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

Injectable Reactive Oxygen Species-Responsive SN38 Prodrug Scaffold with Checkpoint Inhibitors for Combined Chemoimmunotherapy

Yimou Gong et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(ii) complex, leading to prompt cell apoptosis via photoactivation of a prodrug

Amrita Chaudhuri et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Engineering, Biomedical

Highly potent monomethyl auristatin E prodrug activated by caspase-3 for the chemoradiotherapy of triple-negative breast cancer

Seung Woo Chung et al.

BIOMATERIALS (2019)

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Article Biochemistry & Molecular Biology

Machine Learning Approach for Determining the Formation of -Lactam Antibiotic Complexes with Cyclodextrins Using Multispectral Analysis

Mikolaj Mizera et al.

MOLECULES (2019)

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Article Chemistry, Multidisciplinary

Nanoscale Coordination Polymers for Synergistic NO and Chemodynamic Therapy of Liver Cancer

Yihui Hu et al.

NANO LETTERS (2019)

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Article Nanoscience & Nanotechnology

Self-Strengthened Oxidation-Responsive Bioactivating Prodrug Nanosystem with Sequential and Synergistically Facilitated Drug Release for Treatment of Breast Cancer

Kaiyuan Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor

Soo Zeng Fiona Phua et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

A Hypoxia-Responsive Albumin-Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

Guangbao Yang et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

NIR-Light-Activated Combination Therapy with a Precise Ratio of Photosensitizer and Prodrug Using a Host-Guest Strategy

Hongzhong Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Activation of Prodrugs by NIR-Triggered Release of Exogenous Enzymes for Locoregional Chemo-photothermal Therapy

Li Cheng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Chemistry, Multidisciplinary

Self-Assembled Responsive Bilayered Vesicles with Adjustable Oxidative Stress for Enhanced Cancer Imaging and Therapy

Jibin Song et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Chemistry, Multidisciplinary

Pursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes

Fei Xiong et al.

NANO LETTERS (2019)

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Review Biotechnology & Applied Microbiology

Applications of machine learning in drug discovery and development

Jessica Vamathevan et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Nanoscience & Nanotechnology

Self-Assembled Indomethacin Dimer Nanoparticles Loaded with Doxorubicin for Combination Therapy in Resistant Breast Cancer

Xin Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Linye Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Oncology

Reactive oxygen species and cancer: A complex interaction

Sankaralingam Saikolappan et al.

CANCER LETTERS (2019)

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Article Chemistry, Multidisciplinary

Polymersome nanoreactors with tumor pH-triggered selective membrane permeability for prodrug delivery, activation, and combined oxidation-chemotherapy

Jean Felix Mukerabigwi et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Multidisciplinary Sciences

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

Bingjun Sun et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

Wenjia Zhang et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Reactive Oxygen Species-Activatable Liposomes Regulating Hypoxic Tumor Microenvironment for Synergistic Photo/Chemodynamic Therapies

Zhihao Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Combretastatin A4 Nanodrug-Induced MMP9 Amplification Boosts Tumor-Selective Release of Doxorubicin Prodrug

Jian Jiang et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

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Hammerhead ribozyme against γ-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins

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Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

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