4.8 Review

Emerging Strategies in Stimuli-Responsive Prodrug Nanosystems for Cancer Therapy

期刊

ACS NANO
卷 16, 期 9, 页码 13513-13553

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c05379

关键词

biomedical nanotechnology; cancer therapy; controlled release; drug delivery; nanomedicine; nanoscale prodrugs; on-demand activation; stimuli responsiveness

资金

  1. Guangdong Medical Science and Technology Research Fund [BS2021001]
  2. Maoming People's Hospital [BS2021001]
  3. Guangdong Medical Science and Technology Research Fund [NRF-NRFI2018-03]
  4. Tianjin Key Laboratory of Biomedical Materials
  5. National Natural Science Foundation of China [BS2021001]
  6. Singapore National Research Foundation Investigatorship [A2021213]
  7. [32101065]

向作者/读者索取更多资源

Prodrugs are inactive drug molecules that are converted to active drugs after administration. They play a crucial role in drug treatment, especially in cancer therapy. Current research focuses on stimuli-responsive activation mechanisms, regulation of stimuli intensity in vivo, and the design of nanoscale prodrug formulations.
Prodrugs are chemically modified drug molecules that are inactive before administration. After administration, they are converted in situ to parent drugs and induce the mechanism of action. The development of prodrugs has upgraded conventional drug treatments in terms of bioavailability, targeting, and reduced side effects. Especially in cancer therapy, the application of prodrugs has achieved substantial therapeutic effects. From serendipitous discovery in the early stage to functional design with pertinence nowadays, the importance of prodrugs in drug design is self-evident. At present, studying stimuli-responsive activation mechanisms, regulating the stimuli intensity in vivo, and designing nanoscale prodrug formulations are the major strategies to promote the development of prodrugs. In this review, we provide an outlook of recent cutting-edge studies on stimuli-responsive prodrug nanosystems from these three aspects. We also discuss prospects and challenges in the future development of such prodrugs.

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