Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism

Constipation can seriously affect the quality of life and increase the risk of colorectal cancer. The present strategies for constipation therapy have adverse effects, such as causing irreversible intestinal damage and affecting the absorption of nutrients. Nanocrystalline cellulose (NCC), which is from natural plants, has good biocompatibility and high safety. Herein, we used NCC to treat constipation assessed by the black stool, intestinal tissue sections, and serum biomarkers. We studied the effect of NCC on gut microbiota and discussed the correlation of gut microbiota and metabolites. We evaluated the long-term biosafety of NCC. NCC could effectively treat constipation through gut microbiota metabolism, which required a small dosage and did not affect the organs and intestines. NCC could be used as an alternative to medications and dietary fiber for constipation therapy.

Automated summary

In this study, nanocrystalline cellulose (NCC) was used to treat constipation, and the efficacy was evaluated through the assessment of stool color, intestinal tissue sections, and serum biomarkers. The study found that NCC effectively treated constipation by modulating gut microbiota metabolism, without adverse effects on organs and intestines.