期刊
ACS NANO
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c06306
关键词
spiral ganglion neuron; hydrogel; cochlear implant; electroacoustic stimulation
类别
资金
- National Key R&D Program of China [2021YFA1101300, 2020YFA0112503]
- Strategic Priority Research Program of the Chinese Academy of Science [XDA16010303]
- National Natural Science Foundation of China [82030029, 81970882, 81970883, 92149304]
- Natural Science Foundation of Jiangsu Province [BE2019711]
- Science and Technology Department of Sichuan Province [2021YFS0371]
- Shenzhen Fundamental Research Program [JCYJ20190814093401920, JCYJ20210324125608022]
- Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University [SKLGE-2104]
Cochlear implantation is the most effective treatment method for patients with profound and total hearing loss. This study presents an electrical stimulation system combining a cochlear implant and a conductive Ti3C2Tx MXene-matrigel hydrogel, which promotes the growth and signal transmission of spiral ganglion neurons, potentially improving the postoperative listening effect of cochlear implantation.
Cochlear implantation has become the most effective treatment method for patients with profound and total hearing loss. However, its therapeutic efficacy is dependent on the number and normal physiological function of cochlear implant-targeted spiral ganglion neurons (SGNs). Electrical stimulation can be used as an effective cue to regulate the morphology and function of excitatory cells. Therefore, it is important to develop an efficient cochlear implant electroacoustic stimulation (EAS) system to study the behavior of SGNs. In this work, we present an electrical stimulation system constructed by combining a cochlear implant and a conductive Ti3C2Tx MXene-matrigel hydrogel. SGNs were cultured in the Ti3C2Tx MXene-matrigel hydrogel and exposed to electrical stimulation transduced by the cochlear implant. It was demonstrated that low-frequency stimulation promoted the growth cone development and neurite outgrowth of SGNs as well as signal transmission between cells. This work may have potential value for the clinical application of the Ti3C2Tx MXene hydrogel to optimize the postoperative listening effect of cochlear implantation and benefit people with sensorineural hearing loss.
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