4.6 Article

Dopaminergic Neurons Differentiated from LRRK2 I1371V-Induced Pluripotent Stem Cells Display a Lower Yield, a-Synuclein Pathology, and Functional Impairment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Generation of induced pluripotent stem cells (NIMHi004-A, NIMHi005-A and NIMHi006-A) from healthy individuals of Indian ethnicity with no mutation for Parkinson's disease related genes

Soham Jagtap et al.

Summary: This study describes the generation and characterization of three induced pluripotent stem cell lines derived from peripheral blood mononuclear cells of healthy individuals. These cell lines were generated using non-integrating Sendai virus vectors. The study also found that the donors did not carry any mutations associated with the occurrence and progression of Parkinson's disease and did not have any chromosomal abnormalities.

STEM CELL RESEARCH (2022)

Article Cell Biology

A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Petros Stathakos et al.

Summary: Macroautophagy/autophagy cytoplasmic quality control pathways are crucial for neural development and maintaining functional neuronal populations in the adult brain. Declining neuronal autophagy pathways contribute to neurodegenerative diseases, including Parkinson's disease, highlighting the need for reliable human neuronal model systems for research and therapeutic interventions. HiPSC neural model systems show promise in meeting this demand but may face limitations in generating ventral midbrain dopaminergic neurons efficiently for functional and imaging-based in vitro assays.

AUTOPHAGY (2021)

Review Neurosciences

Therapeutic Potential of Vital Transcription Factors in Alzheimer's and Parkinson's Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy

Sachchida Nand Rai et al.

Summary: Autophagy is essential for cellular homeostasis, and dysregulation in this pathway is implicated in neurodegenerative disorders. TFEB, a key regulator of autophagy and lysosomal biogenesis, is considered a potential therapeutic target for treating these disorders. Studies have shown that targeting TFEB may help alleviate neurotoxicity and rescue neurodegeneration in animal models, providing insights for potential therapeutic strategies in neurodegenerative disorders.

FRONTIERS IN NEUROSCIENCE (2021)

Article Clinical Neurology

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils

Ying Fan et al.

Summary: This study found a significant increase in pRab10(Thr73) phosphorylation in carriers of the LRRK2 R1441G mutation, whereas the effect of the LRRK2 G2019S mutation was not statistically significant. Analysis of pRab10(Thr73) phosphorylation in post-mortem brain samples revealed high variability mainly due to the adverse effects of the peri- and post-mortem period on protein phosphorylation stability.

ACTA NEUROPATHOLOGICA (2021)

Article Cell & Tissue Engineering

In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation

Kuo-Hsuan Chang et al.

Summary: This study compared the mutation correction efficiency and off-target effects between HDR and ABEs in iPSCs carrying the LRRK2 c.G6055A (p.G2019S) mutation. Results showed that ABE had a higher correction rate (24.5%) but no off-target effects, while HDR had a higher deletion rate (57.4%) but no ABE clones. The corrected iPSC-derived dopaminergic neurons exhibited reduced LRRK2 kinase activity, decreased phospho-alpha-synuclein expression, and mitigated neurite shrinkage and apoptosis. Transciptomic and proteomic analysis identified differences in gene expression related to energy metabolism, protein degradation, and peroxisome proliferator-activated receptor pathways between mutant and isogenic control cells.

STEM CELL RESEARCH & THERAPY (2021)

Review Cell Biology

Promising drug targets and associated therapeutic interventions in Parkinson's disease

Sachchida Nand Rai et al.

Summary: Parkinson's disease is a debilitating brain disease with limited treatment options, highlighting the need for novel drug targets to improve patient health. Natural products may play a critical role in controlling the progression of Parkinson's disease.

NEURAL REGENERATION RESEARCH (2021)

Article Physiology

Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells

Sangeeta Bhallamudi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Advancement in the modelling and therapeutics of Parkinson's disease

Sachchida Nand Rai et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2020)

Article Cell & Tissue Engineering

Evaluating In Vitro Neonatal Hypoxic-Ischemic Injury Using Neural Progenitors Derived from Human Embryonic Stem Cells

Sowmithra Sowmithra et al.

STEM CELLS AND DEVELOPMENT (2020)

Review Neurosciences

Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants - Let's get even more personal

Christian U. von Linstow et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Review Biotechnology & Applied Microbiology

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

Sachchida Nand Rai et al.

3 BIOTECH (2020)

Review Biochemistry & Molecular Biology

Role of the endolysosomal system in Parkinson's disease

D. J. Vidyadhara et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Review Medicine, General & Internal

Impact of ethnicity on the natural history of Parkinson disease

Anna Sauerbier et al.

MEDICAL JOURNAL OF AUSTRALIA (2018)

Article Neurosciences

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Hibiki Kawamata et al.

MOLECULAR NEURODEGENERATION (2017)

Article Cell Biology

Emerging biological roles of Cl- intracellular channel proteins

Elisabetta Argenzio et al.

JOURNAL OF CELL SCIENCE (2016)

Article Biochemistry & Molecular Biology

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

Senthilkumar S. Karuppagounder et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2016)

Article Immunology

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons

Rakel Lopez de Maturana et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Article Cell Biology

Molecular identity of cardiac mitochondrial chloride intracellular channel proteins

Devasena Ponnalagu et al.

MITOCHONDRION (2016)

Article Biotechnology & Applied Microbiology

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity

Dong Hwan Ho et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Neurosciences

The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease

Ignacio F. Mata et al.

MOLECULAR NEURODEGENERATION (2015)

Article Biochemistry & Molecular Biology

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration

Edward D. Plowey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Biochemistry & Molecular Biology

DNAJC13 mutations in Parkinson disease

Carles Vilarino-Gueell et al.

HUMAN MOLECULAR GENETICS (2014)

Article Cell Biology

CLIC4 regulates cell adhesion and β1 integrin trafficking

Elisabetta Argenzio et al.

JOURNAL OF CELL SCIENCE (2014)

Article Neurosciences

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance

Andrii Domanskyi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Cell & Tissue Engineering

The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells

Lamia'a Bahnassawy et al.

STEM CELLS AND DEVELOPMENT (2013)

Article Biotechnology & Applied Microbiology

Evaluation of the role of LRRK2 gene in Parkinson's disease in an East Indian cohort

Tamal Sadhukhan et al.

DISEASE MARKERS (2012)

Article Genetics & Heredity

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

Alexander Zimprich et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Genetics & Heredity

VPS35 Mutations in Parkinson Disease

Carles Vilarino-Gueell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Cell & Tissue Engineering

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

Ha Nam Nguyen et al.

CELL STEM CELL (2011)

Article Neurosciences

LRRK2 G2019S mutation does not contribute to Parkinson's disease in South India

Bejoy Vijayan et al.

NEUROLOGY INDIA (2011)

Article Medicine, Research & Experimental

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5

Hye Young Heo et al.

Experimental Neurobiology (2011)

Article Biochemistry & Molecular Biology

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

Hong Qing et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Review Biochemistry & Molecular Biology

Can cellular models revolutionize drug discovery in Parkinson's disease?

Birgitt Schuele et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Biochemistry & Molecular Biology

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

Christian L. Klein et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Genetics & Heredity

Genome-wide association study reveals genetic risk underlying Parkinson's disease

Javier Simon-Sanchez et al.

NATURE GENETICS (2009)

Article Clinical Neurology

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross et al.

ANNALS OF NEUROLOGY (2008)

Article Genetics & Heredity

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence

E. K. Tan et al.

HUMAN GENETICS (2008)

Article Multidisciplinary Sciences

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

Junpeng Deng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Green fluorescent protein impairs actin-myosin interactions by binding to the actin-binding site of myosin

Onnik Agbulut et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Clinical Neurology

Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation

Maria Teresa Giordana et al.

MOVEMENT DISORDERS (2007)

Article Clinical Neurology

Lrrk2 and Lewy body disease

OA Ross et al.

ANNALS OF NEUROLOGY (2006)

Article Clinical Neurology

Biochemical and pathological characterization of Lrrk2

BI Giasson et al.

ANNALS OF NEUROLOGY (2006)

Article Biochemistry & Molecular Biology

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

CJ Gloeckner et al.

HUMAN MOLECULAR GENETICS (2006)

Article Pharmacology & Pharmacy

Capsaicin stimulates the non-store-operated Ca2+ entry but inhibits the store-operated Ca2+ entry in neutrophils

JP Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)

Article Multidisciplinary Sciences

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

EM Valente et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Animal models of Parkinson's disease

R Betarbet et al.

BIOESSAYS (2002)

Article Cell Biology

α-Synuclein is phosphorylated in synucleinopathy lesions

H Fujiwara et al.

NATURE CELL BIOLOGY (2002)

Article Clinical Neurology

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1

M Funayama et al.

ANNALS OF NEUROLOGY (2002)

Article Biotechnology & Applied Microbiology

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells

SH Lee et al.

NATURE BIOTECHNOLOGY (2000)