期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 44, 页码 49454-49470出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c11284
关键词
upconversion nanoparticle; near-infrared; glioblastoma; cRGD bioorthogonal labeling; yolk-shell structure
资金
- Natural Science Foundation of Guangxi Province [2019JJA140599, 2019GXNSFAA245095]
- Guangxi Science and Technology Plan Project [Guike AD17129015]
- Health Commission of Guangxi [ZTJ2020005]
- Science and Technology Department of Guangxi [Guike ZY21195042]
- Guilin Scientific Research and Technology Development Program [20190219-2]
- Natural Science Foundation of China [81860629, 86120520]
This study successfully prepared a novel nanoparticle drug for the treatment of glioblastoma. The nanoparticles can release reactive oxygen species through near-infrared radiation, enhancing cytotoxicity. The decorated cell membrane allows the nanoparticles to efficiently bypass the blood-brain barrier and specifically target glioblastoma cells.
Glioblastoma is hard to be eradicated partly because of the obstructive blood-brain barrier (BBB) and the dynamic autophagy activities of glioblastoma. Here, hydroxychloroquine (HDX)-loaded yolk-shell upconversion nanoparticle (UCNP)@ Zn0.5Cd0.5S nanoparticle coating with the cyclic Arg-Gly-Asp (cRGD)-grafted glioblastoma cell membrane for near-infrared (NIR)-triggered treatment of glioblastoma is prepared for the first time. UCNPs@Zn0.5Cd0.5S (abbreviated as YSN, yolk-shell nanoparticle) under NIR radiation will generate reactive oxygen species for imposing cytotoxicity. HDX, the only available autophagy inhibitor in clinical studies, can enhance cytotoxicity by preventing damaged organelles from being recycled. The cRGD-decorated cell membrane allowed the HDX-loaded nanoparticles to efficiently bypass the BBB and specifically target glioblastoma cells. Exceptional treatment efficacy of the NIR-triggered chemotherapy and photodynamic therapy was achieved in U87 cells and in the mouse glioblastoma model as well. Our results provided proof-of-concept evidence that HDX@YSN@CCM@cRGD could overcome the delivery barriers and achieve targeted treatment of glioblastoma.
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