Three-Dimensional Covalent Organic Framework with scu-c Topology for Drug Delivery br

Three-dimensional (3D) covalent organic frameworks (COFs) exemplify a new generation of crystalline extended solids with intriguing structures and unprecedented porosity. Notwithstanding substantial scope, the reticular synthesis of 3D COFs from pre-designed building units leading to new network topologies yet remains a demanding task owing to the shortage of 3D building units and inadequate reversibility of the linkages between the building units. In this work, by linking a tetragonal prism (8-connected) node with a square planar (4-connected) node, we report the first 3D COF with scu-c topology. The new COF, namely, TUS-84, features a two-fold interpenetrated structure with well-defined porosity and a Brunauer- Emmett-Teller surface area of 679 m2 g-1. In drug delivery applications, TUS-84 shows efficient drug loading and sustained release profile.

Automated summary

Three-dimensional covalent organic frameworks (COFs) are a new type of crystalline solids with intriguing structures and porosity. Synthesizing 3D COFs from pre-designed building units remains challenging due to the lack of suitable units and reversible linkages. In this study, a new 3D COF, TUS-84, was reported by linking a tetragonal prism node with a square planar node, exhibiting a two-fold interpenetrated structure, well-defined porosity, and high surface area. TUS-84 also demonstrated efficient drug loading and sustained release profile in drug delivery applications.