期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 37, 页码 42568-42577出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c13982
关键词
4D printing; shape memory composites; light-active; light-thermal therapy; smart structure
资金
- National Natural Science Foundation of China [11802075, 11632005]
- Central University Basic Research Fund of China [IR2021232, IR2021106]
4D printing is used to fabricate smart medical structures with remote control capability and therapeutic function. It incorporates gold nanoparticles into a shape memory polyurethane matrix to create a multifunctional composite with good mechanical properties and light-active shape memory. The composites demonstrate rapid and stable light-thermal effects for localized and controlled tumor ablation. Additionally, 4D-printed structures can quickly recover their shape under light exposure, offering potential for minimally invasive treatment.
4D printing is an advanced manufacturing technol-ogy combining additive manufacturing with smart materials. Based on light-active shape memory composites, smart medical structures with remote control capability, therapeutic function, and biocompatibility are hopefully fabricated by 4D printing. Here, a multifunctional composite with good mechanical properties, biocompatibility, and light-active shape memory performance is prepared by incorporating gold nanoparticles into a shape memory polyurethane matrix. The composites demonstrate a rapid and stable light-thermal effect, which can achieve localized and controlled breast tumor ablation, providing an approach to hyperthermia treatment for cancer cells. By directly bioprinting the composite melt, a series of 4D-printed structures are manufactured accurately in a convenient, clean, and safe way, which show a fast autonomous light-driven shape recovery process. The examples of a 4D-printed soft tissue scaffold and intraluminal scaffold can expand from a conveniently insertional shape to an expanded shape under light exposure. The proposed strategies provide great inspiration for customized multifunctional light-thermal therapeutic structures for minimally invasive treatment.
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