☆ 4.8 Review

From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Summary: This study presents a molecular strategy that enhances the efficacy of photodynamic therapy (PDT) by utilizing ascorbate chemistry. The strategy targets cancer cells overexpressing glucose transporter 1 (GLUT1) and disrupts tumor redox homeostasis, leading to improved therapeutic responses. The approach shows promising synergistic effects in vitro and in vivo.

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