Does an Intradermal Vaccination for Monkeypox Make Sense?

Article Chemistry, Medicinal

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Y. Tian et al.

Summary: This study demonstrates the potential of trehalose/pullulan-based dissolving-microneedle-arrays (dMNAs) as an alternative dosage form for influenza vaccination. The produced dMNAs have sufficient mechanical strength and stability to penetrate ex vivo human skin and dissolve within a short period of time to release antigens. Immunization of mice with influenza antigens via freshly prepared or stored dMNAs resulted in antibody titers comparable to intramuscularly injected mice, providing partial protection against influenza virus infection.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

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Article Immunology

Performance and usability evaluation of novel intradermal injection device ImmuciseTM and reanalysis of intradermal administration trials of influenza vaccine for the elderly

Sakiko Shimizu et al.

Summary: Under the pandemic situation, there is a need for sufficient prophylactic vaccines. Intradermal (ID) vaccination is an effective method, but currently not widely used due to technical difficulties. This study presents the design and performance testing results of the ImmuciseTM Intradermal Injection System. The study shows that ImmuciseTM can inject drugs precisely into the ID tissues and is safe to use. An analysis comparing ID administration with standard subcutaneous (SC) administration of influenza vaccine shows that ID administration is equally or more effective up to 180 days later. These findings suggest that ImmuciseTM is an efficient device for distributing a small amount of vaccine widely during a pandemic.

VACCINE (2022)

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Editorial Material Biology

SKIN IMMUNITY A new player in the dermis

Gyohei Egawa et al.

Summary: Langerhans-like cells in the dermis can migrate to lymph nodes and modulate immune responses.

ELIFE (2021)

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Review Health Care Sciences & Services

Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?

Alberto Migliore et al.

Summary: The narrative review suggests that fractional intradermal vaccination can be an effective and efficient strategy for certain vaccines such as influenza, rabies, and hepatitis B. More research is needed for vaccines against other pathogens, but initial findings are promising. During a shortage of COVID-19 vaccines, exploring fractional dosing schemes could help save doses and achieve herd immunity quickly.

RISK MANAGEMENT AND HEALTHCARE POLICY (2021)

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Article Immunology

Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

John S. Tregoning et al.

Summary: The development and rollout of vaccines have brought hope for controlling the COVID-19 pandemic, with vaccines proving highly effective in preventing disease. However, challenges remain in ensuring equitable access to vaccines globally, as well as lessons to be learned for controlling pandemics in the future.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Immunology