期刊
JOURNAL OF GENETICS AND GENOMICS
卷 43, 期 5, 页码 251-262出版社
SCIENCE PRESS
DOI: 10.1016/j.jgg.2016.03.001
关键词
CRISPR/Cas technology; Genome editing; Gene knockout; Plants
资金
- National Natural Science Foundation of China [31522006, 31570276]
- Sun Yat-sen University
- China's Thousand Young Talents Program
The CRISPR/Cas technology is emerging as a revolutionary genome editing tool in diverse organisms including plants, and has quickly evolved into a suite of versatile tools for sequence-specific gene manipulations beyond genome editing. Here, we review the most recent applications of the CRISPR/Cas toolkit in plants and also discuss key factors for improving CRISPR/Cas performance and strategies for reducing the off-target effects. Novel technical breakthroughs in mammalian research regarding the CRISPR/Cas toolkit will also be incorporated into this review in hope to stimulate prospective users from the plant research community to fully explore the potential of these technologies.
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