Medicinal phytometabolites synthesis using yeast bioengineering platform

Large-scale production of natural plant products has become a necessity for a wide range of applications in human health and industry. In recent years, yeast has become a potential biotechnological and bioengineering platform for the production of industrially relevant biochemicals, pharmaceuticals, and biofuels which are often not easy to produce by chemical mode and are generally derived via cumbersome extraction methods from bioresources including plants. The yeast system has been extensively used for the heterologous production of many natural products and/or their precursors owing to certain merits such as availability of highly efficient promoters for heterologous expression, codon optimization, suitable selection markers, co-transformation efficiency, and multiple expression constructs. Consequent to the availability of yeast genome sequence, and advances in systems and synthetic biology, new avenues have emerged for designing metabolic engineering strategies towards the synthesis of plant based metabolites. Herein, we have presented an account of the developments and challenges in employing yeast as a prospective platform for the production of some plant derived bioactive metabolites.

Automated summary

This article presents the developments and challenges in using yeast as a prospective platform for the production of plant derived bioactive metabolites.