期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 31, 期 5, 页码 980-987出版社
WILEY-BLACKWELL
DOI: 10.1111/jgh.13241
关键词
non-alcoholic fatty liver disease; polycystic ovary syndrome; community; obesity; testosterone; Raine study; insulin resistance; C-reactive protein
资金
- National Health and Medical Research Council [403968, 634445, 353514, 403981, 404166, 1058935, 1042370]
- Gastroenterology Society of Australia (Astra Zeneca Career Development Award)
- Fremantle Hospital Medical Research Foundation
- University of Western Australia Ada Bartholomew grant
- National Health and Medical Research Council of Australia [1058935] Funding Source: NHMRC
Background and Aims:Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) share risk associations of adiposity and insulin resistance. We examined the impact of a PCOS diagnosis on the metabolic phenotype of adolescent girls with NAFLD and compared this to girls without PCOS or NAFLD and to age-matched boys. Methods:Community-based adolescents from the Raine Cohort participated in assessments for NAFLD (572 girls and 592 boys) and PCOS (244 girls). One hundred and ninety-nine girls attended both assessments. Results:Amongst the 199 girls, PCOS was diagnosed in 16.1% and NAFLD in 18.6%. NAFLD was diagnosed in 10.1% of the boys. NAFLD was more prevalent in girls with PCOS than girls without PCOS (37.5% vs 15.1%, P=0.003). Girls with NAFLD plus PCOS had greater adiposity (waist circumference, body mass index, suprailiac skinfold thickness [SST], serum androgens, high-sensitivity C-reactive protein, ferritin, homeostasis model assessment for insulin resistance (HOMA-IR), and lower serum sex hormone binding globulin levels than girls with NAFLD without a PCOS diagnosis (all P<0.05). Girls with NAFLD plus PCOS had similar adiposity, HOMA-IR, and adiponectin levels to boys with NAFLD, but more adiposity, serum leptin and HOMA-IR than both girls and boys without NAFLD. PCOS (odds ratios 2.99, 95% confidence intervals 1.01-8.82, P=0.048) and SST (odds ratios 1.14, 95% confidence intervals 1.08-1.20, P<0.001) independently predicted NAFLD in adolescent girls, however, serum androgens and HOMA-IR levels did not. Conclusions:Adolescent girls with NAFLD plus PCOS have a similar metabolic phenotype to boys with NAFLD. Increasing SST and pre-existing PCOS independently predict NAFLD in adolescent girls.
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