A Review of Phytoconstituents as Antibacterial Agents

Background bacteria cause various infectious diseases and cause millions of deaths each year. Bacteria are broadly classified based on the phenotypic and genotypic systems. Bacteria cause resistance mainly by Plasmids, Inactivation of antibiotics, Target site modification, Preventing drug uptake, Efflux pumps, and Biofilm. Plants have been used for thousands of years for their medicinal properties to treat various diseases. Secondary metabolites like terpenes, alkaloids, phenolic compounds, tannins, quinones, steroids, polyketides, aromatics, and peptides are plant-derived compounds that possess antibacterial activity and decrease resistance by inhibition of biofilm formation, Efflux pump [EP] inhibitors, attenuating bacterial virulence, and Immunomodulation activity. Phytoconstituents synergism, combination therapy (Bio-enhancers), and herbal preparation benefit antibacterial potential and decrease resistance.

Automated summary

Background bacteria lead to various infectious diseases and millions of deaths each year. Plant-derived secondary metabolites possess antibacterial activity and can decrease resistance through inhibition of biofilm formation, efflux pump inhibition, attenuation of bacterial virulence, and immunomodulation activity.