Understanding the role of mechanics in nucleocytoplasmic transport

Cell nuclei are submitted to mechanical forces, which in turn affect nuclear and cell functions. Recent evidence shows that a crucial mechanically regulated nuclear function is nucleocytoplasmic transport, mediated by nuclear pore complexes (NPCs). Mechanical regulation occurs at two levels: first, by force application to the nucleus, which increases NPC permeability likely through NPC stretch. Second, by the mechanical properties of the transported proteins themselves, as mechanically labile proteins translocate through NPCs faster than mechanically stiff ones. In this perspective, we discuss this evidence and the associated mechanisms by which mechanics can regulate the nucleo-cytoplasmic partitioning of proteins. Finally, we analyze how mechanical regulation of nucleocytoplasmic transport can provide a systematic approach to the study of mechanobiology and open new avenues both in fundamental and applied research. (C) 2022 Author(s).

Automated summary

Cell nuclei are affected by mechanical forces, especially through the mechanical regulation of nucleocytoplasmic transport mediated by nuclear pore complexes. Mechanical forces can increase the permeability of nuclear pore complexes by exerting force on the nucleus, and the mechanical properties of transported proteins can also regulate the rate of nucleocytoplasmic transport.